6533b82efe1ef96bd12929b9
RESEARCH PRODUCT
Burden of cardiovascular risk factors and cardiovascular disease in childhood cancer survivors: Data from the German CVSS-study.
Hannelore NeuhauserHannelore NeuhauserPeter KaatschWolfgang RathmannChristine MeisingerPhilipp S. WildMarie A. NeuThomas MünzelAstrid SchneiderK.j. LacknerNicole HenningerMarina Panova-noevaManfred E. BeutelArthur WingerterJörg FaberBirgit LinkohrHiltrud MerzenichMaria BlettnerAnnette PetersAnnette PetersClaudia SpixJürgen H. ProchaskaSusan Eckerlesubject
AdultMalemedicine.medical_specialtyPopulationComorbidity030204 cardiovascular system & hematologyYoung Adult03 medical and health sciences0302 clinical medicineCancer SurvivorsRisk FactorsGermanyDiabetes mellitusInternal medicineDiabetes MellitusPrevalenceHumansMedicineObesityAge of OnsetSex DistributionYoung adulteducationeducation.field_of_studybusiness.industrySmokingMiddle Agedmedicine.diseaseComorbidityConfidence intervalCardiotoxicity ; Long-term Survivors ; Late Sequelae ; Cardiovascular Morbidity ; Cardio-oncologyCardiovascular Diseases030220 oncology & carcinogenesisRelative riskCohortFemaleAge of onsetCardiology and Cardiovascular Medicinebusinessdescription
Aims: The cardiac and vascular late sequelae in long-term survivors of childhood cancer (CVSS)-study aimed to quantify the prevalence of cardiovascular risk factors (CVRF) and cardiovascular disease (CVD) in German childhood cancer survivors (CCS). Methods and results: In the CVSS-study (NCT02181049), 1002 CCS (age range 23-48 years) diagnosed with neoplasia prior to 15 years of age between 1980 and 1990 prospectively underwent a systematic, standardized clinical and laboratory cardiovascular screening, identical to the population-based Gutenberg Health Study (GHS) cohort. For 951 individuals, prevalences of CVRF and CVD were primarily compared to the GHS sample and to two further German population-based cohorts. Using log-binomial regression models, an increased risk for occurrence of arterial hypertension [relative risk (RR) 1.38, 95% confidence interval (95% CI 1.21-1.57)] and dyslipidaemia [RR 1.26 (95% CI 1.12-1.42)] was found. This indicates a premature occurrence compared to the general population of approximately 6 and 8 years, respectively [rate advancement period estimator, RAPhypertension 5.75 (95% CI 3.5-8.0) and RAPdyslipidaemia 8.16 (95% CI 4.4-11.9)]. Overall, no differences were observed for obesity and diabetes. Overt CVD was present in 4.5% (95% CI 3.0-6.6%) of CCS [RR 1.89 (95% CI 1.34-2.66), RAPCVD 7.9 (95% CI 4.1-11.7)], of which the most frequent entities were congestive heart failure and venous thromboembolism. Prevalences of CVRF and CVD increased with age without reaching a plateau over time. Conclusion: This large CCS screening examination revealed consistently in comparison to three population samples a considerably increased risk for premature CVD. The findings in these young adult CCS indicate a high burden of cardiovascular morbidity and mortality in the long term. Clinicaltrials. gov-Nr: NCT02181049.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-01-01 |