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RESEARCH PRODUCT
Evaluation of early and late histamine release by three standard volume substitutes
Dan G. DudaBenno StinnerIlhan CelikH GajekWilfried Lorenzsubject
medicine.medical_specialtybusiness.industryHuman albuminPharmacologyHydroxyethyl starchCritical Care and Intensive Care MedicinePlasma Substituteschemistry.chemical_compoundchemistryConcomitantPolygelineEmergency medicineMeeting AbstractmedicinebusinessClinical scenarioHistaminemedicine.drugdescription
Following meta-analysis [1], the use of colloidal solutions in intensive care medicine is under discussion. Although polygeline [2] and human albumin are known to cause histamine release, other substances eg hydroxyethyl starch were thought to be without effect. Histamine release depends on the clinical scenario, concomitant drugs, infusion speed, duration and amount of infusion. However, there is no information about their effect regarding time periods longer than immediate reactions. This study investigated the histamine releasing effects of three plasma substitutes administered and observed over a longer period of time, simulating many of the clinical scenarios.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2001-03-01 | Critical Care |