6533b82efe1ef96bd12930d9
RESEARCH PRODUCT
Imaging of LED-excited autofluorescence photobleaching rates for skin diagnostics
Dmitrijs BliznuksEmilija Vija PlorinaAleksandrs DerjaboMarta LangeIlze LihacovaAlexey Lihachevsubject
Autofluorescencemedicine.medical_specialtyMaterials scienceMelanomaExcited statemedicineSkin cancermedicine.diseasePhotobleachingPower densityIntensity (physics)Biomedical engineeringSpectral imagingdescription
The aim of this study is to develop a novel non-invasive approach for skin cancer (melanoma, basal cell and squamous cell carcinomas) diagnostics by mapping the AF intensity decrease (photo-bleaching) rates under continuous 405 nm LED excitation. For parametric mapping of skin AF intensity decrease rates a sequence of filtered AF imaging under 405 nm LED excitation for 20 seconds at a power density of ~7 mW/cm2 with a frame rate 0.5 fps was recorded and analyzed by cloud-based prototype device. Several clinical cases and potential future applications of the proposed autofluorescence photobleaching rate imaging technique are discussed.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-07-19 | Clinical and Preclinical Optical Diagnostics II |