6533b82efe1ef96bd1293343

RESEARCH PRODUCT

Extraction, Characterization and Incorporation of Hypericum scruglii Extract in Ad Hoc Formulated Phospholipid Vesicles Designed for the Treatment of Skin Diseases Connected with Oxidative Stress

Anna Maria FaddaMatteo AroffuMaria Letizia MancaHiba N. RajhaHiba N. RajhaJosé Luis PedrazMaria ManconiIris UsachRita Abi RachedTania Belen Lopez-mendezMohamad AllawGianluigi BacchettaMarco PorcedduRichard G. MarounFrancesca Marongiu

subject

food.ingredientlcsh:RS1-441Pharmaceutical Science02 engineering and technologyhypericaceaemedicine.disease_cause01 natural sciencesGelatinArticlelcsh:Pharmacy and materia medicagelatinhyaluronanchemistry.chemical_compoundglycerosomesfoodphospholipid vesiclesscratch assayZeta potentialmedicineoxidative stressHydrogen peroxideLiposome010405 organic chemistryVesiclekeratinocyte uptake021001 nanoscience & nanotechnologyMaltodextrinIn vitro0104 chemical scienceschemistryBiophysics0210 nano-technologyOxidative stress

description

An extract of Hypericum scruglii, an endangered endemic plant of Sardinia (Italy), was prepared and characterized. It was loaded in special phospholipid vesicles, glycerosomes, which were modified by adding maltodextrin (glucidex) and a polymer (gelatin or hyaluronan). The corresponding liposomes were also prepared and used as reference. The vesicles disclosed suitable physicochemical features for skin delivery. Indeed, their mean diameter ranged from 120 to 160 nm, they were homogeneously dispersed (polydispersity index &le

yearjournalcountryeditionlanguage
2020-10-23
10.3390/pharmaceutics12111010http://hdl.handle.net/10810/48942