6533b82efe1ef96bd129347b
RESEARCH PRODUCT
Soluble guanylyl cyclase appears in a specific subset of periglomerular cells in the olfactory bulb
María Gutièrrez-mecinasFrancisco José Martínez-guijarroFrancisco Javier Gracia-llanesAna Isabel Marqués-maríJosé Miguel Blasco-ibáñezCarlos Cresposubject
CalbindinsTyrosine 3-MonooxygenaseSensory systemOlfactionBiologyCalbindinNitric oxidechemistry.chemical_compoundS100 Calcium Binding Protein GOlfactory nerveCalcium-binding proteinAnimalsProtein IsoformsRats WistarMicroscopy Immunoelectrongamma-Aminobutyric AcidNeuronsGeneral NeuroscienceOlfactory PathwaysOlfactory BulbRatsOlfactory bulbchemistryGuanylate CyclaseCalbindin 2FemaleNitric Oxide SynthaseSoluble guanylyl cyclaseNeurosciencedescription
In the brain, nitric oxide acts as an atypical messenger in cellular nonsynaptic transmission. In the olfactory bulb, this gas is produced at the level of the olfactory glomeruli by a subpopulation of periglomerular cells that participates in the first synaptic relay of the olfactory information between the olfactory nerve and the dendritic tufts of principal cells. It has been proposed that nitric oxide modulates intraglomerular synaptic integration of sensory inputs, but its specific role in the glomerular circuitry remains to be understood. In this article, we demonstrate that, in the glomerular circuits, a specific subset of periglomerular cells, most of them expressing the calcium binding protein calbindin D-28 k, expresses the beta1 subunit of the soluble guanylyl cyclase. These cells could be the targets for the action of nitric oxide at the glomerular level via activation of soluble guanylyl cyclase and production of cGMP.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2005-03-01 | European Journal of Neuroscience |