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RESEARCH PRODUCT

Exposed necrotic bone in 183 patients with bisphosphonate-related osteonecrosis of the jaw: Associated clinical characteristics

Judith Murillo-cortesYolanda JiménezJ BaganManuel LeopoldoLeticia Bagan

subject

Malemedicine.medical_specialtymedicine.medical_treatmentFistulaOsteoporosisOdontologíaMaxilares03 medical and health sciencesNecrosis0302 clinical medicineBreast cancermedicineHumansStage (cooking)General DentistryMultiple myelomaUNESCO:CIENCIAS MÉDICASAgedRetrospective StudiesOral Medicine and Pathologybusiness.industryResearchRetrospective cohort study030206 dentistryBisphosphonatemedicine.diseaseSurgeryOtorhinolaryngology030220 oncology & carcinogenesisBisphosphonate-Associated Osteonecrosis of the JawFemaleSurgerySymptom AssessmentOsteonecrosis of the jawbusiness

description

The main objective of our study was to identify oral symptoms and signs most likely to be associated with the exposure of necrotic bone in bisphosphonate-related osteonecrosis of the jaw (BRONJ). The study group consisted of 183 patients with BRONJ. We recorded data on the underlying disease, bisphosphonate used, location of osteonecrosis, symptoms, pain, fistula development, suppuration, infection, exposed necrotic bone, and BRONJ stage. The mean age of the patients was 68.22 ± 12.19 years. The sample included 118 (64.5%) women. Breast cancer and multiple myeloma were the most common underlying diseases, and 50 patients received oral bisphosphonates for osteoporosis. Dental extractions (69.4%) and mandibular location (74.3%) predominated. The only two variables influencing the possibility of necrotic bone exposure were intravenous bisphosphonate administration and the presence of an intraoral fistula (p < 0.05). Intravenous bisphosphonate use and intraoral fistula presence were associated with a major predisposition to bone exposure in patients with BRONJ. Sin financiación 1.671 JCR (2017) Q2, 41/91 Dentistry, Oral Surgery and Medicine UEV

yearjournalcountryeditionlanguage
2017-08-01
10.4317/medoral.22133https://hdl.handle.net/10550/88444