A Simple Microassay for the Determination of Hydrazine in Biological Samples. Effect of Hydrazine and Isoniazid on Liver and Brain Glutathione

6533b82ffe1ef96bd12947b3

RESEARCH PRODUCT

A Simple Microassay for the Determination of Hydrazine in Biological Samples. Effect of Hydrazine and Isoniazid on Liver and Brain Glutathione

Alvarez De Laviada T Romero F J Antón V Antón V Romá J Viña J Sáez G T

subject

Male Health Toxicology and Mutagenesis Metabolite Toxicology Analytical Chemistry chemistry.chemical_compound Blood serum Spectrophotometry Isoniazid medicine Animals Environmental Chemistry Hydrazine (antidepressant)Brain Chemistry Chemical Health and Safety Chromatography medicine.diagnostic_test Isoniazid Metabolism Glutathione Glutathione Rats Hydrazines Liver chemistry Biochemistry Toxicity medicine.drug

description

A simple microassay for the determination of hydrazine in laboratory samples is presented. The colored product of the reaction of p-dimethylaminobenzaldehyde with hydrazine was tested at 470 nm using double-beam mode in different samples. Internal standards and data on blood serum, liver, and brain of rats treated with hydrazine or isoniazid are presented. The tissue glutathione content of these rats was determined, and the possible implication of glutathione in the brain toxicity of hydrazine is discussed.

year	journal	country	edition	language
1987-11-01	Journal of Analytical Toxicology

https://doi.org/10.1093/jat/11.6.260

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