Association Between Uric Acid and Renal Hemodynamics: Pathophysiological Implications for Renal Damage in Hypertensive Patients

6533b82ffe1ef96bd1294862

RESEARCH PRODUCT

Association Between Uric Acid and Renal Hemodynamics: Pathophysiological Implications for Renal Damage in Hypertensive Patients

Giulio Geraci Emilio Nardi Santina Cottone M. Mogavero Giuseppe Mulè Calogero Geraci

subject

Male Settore MED/09 - Medicina Interna Endocrinology Diabetes and Metabolism renal damage Hemodynamics 030204 cardiovascular system & hematology urologic and male genital diseases chemistry.chemical_compound 0302 clinical medicine 030212 general & internal medicine Ultrasonography Doppler Duplex education.field_of_study Renal damage Middle Aged Pathophysiology Hypertension Cardiology Female medicine.symptom Cardiology and Cardiovascular Medicine Glomerular Filtration Rate Adult arterial hypertension medicine.medical_specialty Population Renal function Hypertension and the Kidneys 03 medical and health sciences Internal medicine CKD Internal Medicine medicine Humans Renal Insufficiency Chronic education Aged Settore MED/14 - Nefrologia Renal hemodynamic business.industry renal resistive index Hemodynamics medicine.disease Uric Acid Endocrinology chemistry Albuminuria Uric acid business human activities Kidney disease

description

The role of vascular renal changes in mediating the association between serum uric acid (SUA) and renal damage is unclear. The purposes of this study were to investigate the relationship between SUA and renal resistive index (RRI), assessed by duplex Doppler ultrasonography, and to assess whether hemodynamic renal changes may explain the association between SUA and renal damage in hypertensive patients. A total of 530 hypertensive patients with and without chronic kidney disease were enrolled and divided into SUA tertiles based on sex-specific cutoff values. RRI and albuminuria were greater and glomerular filtration rate (GFR) was lower in the uppermost SUA tertile patients when compared with those in the lowest tertiles (all P<.001). Moreover, SUA strongly correlated with RRI (P<.001) in all patients. However, RRI did not seem to explain the relationship between SUA and renal damage, and GFR significantly related with SUA in the overall population (P<.001) even after adjustment for RRI.

year	journal	country	edition	language
2016-03-25	The Journal of Clinical Hypertension

https://doi.org/10.1111/jch.12812