6533b82ffe1ef96bd1294f5b

RESEARCH PRODUCT

Retarded Elimination of a High-Molecular Enzyme-Substrate-Complex after Hydroxyethyl-Starch-Infusion

H. J. HorstmannH. KöhlerW. Kirch

subject

Enzyme substrate complexmedicine.medical_specialtybiologyChemistryRenal functionHydroxyethyl starchExcretionBasal (phylogenetics)EndocrinologyPharmacokineticsInternal medicinemedicinebiology.proteinAmylaseLipasemedicine.drug

description

During a pharmacokinetic study with hydroxyethyl starch we found, that this plasma substitute induces a regular increase of serum amylase. In 54 patients after infusion of 500 ml 6% hydroxyethyl starch (HES) an increase of serum amylase was observed, which in 51 cases exceeded the upper limit of normal (190 U/l). In most cases serum amylase reached values twice as high as the basal value. Renal function influenced duration of increased serum amylase values, but did not influence maximum increases (201 ±15 U/l; mean ± SEM). In patients with advanced renal failure (GFR = 2–10 ml/min) serum amylase was still markedly elevated after 72 hours (298 ± U/l; mean ± SEM). In patients with normal renal function (GFR > 90 ml/min) serum amylase decreased to 183 ± 40 ml/min (mean ± SEM) within 72 hours without reaching basal values. After infusion of HES no changes in serum lipase nor in amylase or lipase excretion in the duodenal secretion were observed.

yearjournalcountryeditionlanguage
1978-01-01
https://doi.org/10.1007/978-3-642-66896-8_71