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RESEARCH PRODUCT
Influenza vaccine concurrently administered with a combination measles, mumps, and rubella vaccine to young children.
Hanna CzajkaKah Kee TanSherryl BakerW. Abdullah BrooksJohn S. TamSheau Mei ChengYu-lung LauJurgis BojarskasTimo VesikariSungho ChaJerzy PejczAndré VertruyenBruce D. ForrestLucy Chai See LumRuth RappaportPetras KaltenisOh Moh ChayWilliam C. GruberHeinz J. SchmittPiyaporn BowonkiratikachornRobert F. BreimanMaricruz Gutierrez-britoCharissa Borja-taboraBenjamin SablanTaweewong TantracheewathornBee Wah Leesubject
Malemedicine.medical_specialtyMeasles-Mumps-Rubella VaccineInfluenza vaccineAntibodies ViralVaccines AttenuatedRubellaMeaslesDrug IncompatibilityPlacebosRubella vaccineInternal medicineInfluenza HumanmedicineLive attenuated influenza vaccineHumansVaccines CombinedMumpsAdministration IntranasalRubellaGeneral VeterinaryGeneral Immunology and Microbiologybusiness.industryVaccinationPublic Health Environmental and Occupational HealthInfantmedicine.diseaseVaccinationInfectious DiseasesImmunizationInfluenza VaccinesImmunologyMolecular MedicineFemalebusinessMeasles-Mumps-Rubella Vaccinemedicine.drugMeaslesdescription
Children aged 11 to <24 months received 2 intranasal doses of live attenuated influenza vaccine (LAIV) or placebo, 35+/-7 days apart. Dose 1 was administered concomitantly with a combined measles, mumps, and rubella vaccine (Priorix). Seroresponses to measles and mumps were similar between groups. Compared with placebo, response rates to rubella in LAIV+Priorix recipients were statistically lower at a 15 IU/mL threshold (83.9% vs 78.0%) and the prespecified noninferiority criteria were not met. In a post hoc analysis using an alternate widely accepted threshold of 10 IU/mL, the noninferiority criteria were met (93.4% vs 89.8%). Concomitant administration with Priorix did not affect the overall influenza protection rate of LAIV (78.4% and 63.8% against antigenically similar influenza strains and any strain, respectively).
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2010-02-01 | Vaccine |