6533b82ffe1ef96bd129530b

RESEARCH PRODUCT

Lysosomal changes related to ageing and physical exercise in mouse cardiac and skeletal muscles.

A. SalminenHeikki KainulainenVeikko Vihko

subject

Malemedicine.medical_specialtyAgingPhysical ExertionCathepsin DPhysical exerciseCathepsin DLipofuscinLipofuscinCellular and Molecular NeuroscienceMiceInternal medicinemedicineAnimalsExertionYoung adultMolecular BiologyArylsulfatasesGlucuronidasePharmacologybusiness.industryMusclesMyocardiumCardiac muscleSkeletal muscleCell BiologyAnatomyCathepsinsmedicine.anatomical_structureEndocrinologyAgeingMolecular MedicinebusinessLysosomes

description

Physical exercise increased the activities of arylsulphatase, cathepsin D and β-glucuronidase in mouse skeletal muscle but not in cardiac muscle. Exercise-induced lysosomal response was more prominent in young adult than in senescent mice. The lipofuscin content of cardiac and skeletal muscles increased markedly during ageing and was also found to increase slightly after exertion in young mice, but not in senescent ones.

yearjournalcountryeditionlanguage
1982-07-01Experientia
10.1007/bf01972267https://pubmed.ncbi.nlm.nih.gov/7106245