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RESEARCH PRODUCT

NREM Sleep Instability in Pediatric Migraine Without Aura

Michele RoccellaRosa MarottaFrancesca Felicia OpertoDaniela SmirniFrancesco PrecenzanoIlaria BitettiGiovanni MessinaFrancesco SessaGiulio Di MizioCarla LoretoMonica SalernoVincenzo RussoPaolo MurabitoBeatrice GallaiMaria EspositoDiego IaconoDiego IaconoDiego IaconoMarco Carotenuto

subject

Pediatric migrainemedicine.medical_specialtyNREM sleep instabilityAuraPopulationmigraine without aura (MoA)sleep macrostructureNon-rapid eye movement sleeplcsh:RC346-42903 medical and health sciences0302 clinical medicineInternal medicinemigraine without aura (MoA) NREM sleep instability cyclic alternating pattern (CAP) analysis sleep macrostructure full overnight polysomnographymedicineeducationfull overnight polysomnographylcsh:Neurology. Diseases of the nervous systemOriginal Researcheducation.field_of_studyCyclic alternating pattern (CAP) analysis; Full overnight polysomnography; Migraine without aura (MoA); NREM sleep instability; Sleep macrostructureSettore M-PSI/02 - Psicobiologia E Psicologia Fisiologicabusiness.industrycyclic alternating pattern (CAP) analysisMean agemedicine.diseaseSleep in non-human animalsSettore MED/39 - Neuropsichiatria Infantile030228 respiratory systemMigraineNeurologyCardiologyCyclic alternating pattern (CAP) analysiNeurology (clinical)business030217 neurology & neurosurgerySleep duration

description

Children with migraine headaches appear to have a range of sleep disturbances. The aim of the present study was to assess the NREM sleep instability in a population of school-aged individuals affected by migraine without aura (MoA). Thirty-three children with MoA (20 males, 13 females, mean age 10.45 ± 2.06 years) underwent to overnight Polysomnographic (PSG) recordings and Cyclic Alternating Pattern (CAP) analyses accordingly with international criteria. MoA group showed a reduction in sleep duration parameters (TIB, SPT, TST; p ≤ 0.001 for all) and in arousal index during REM sleep and an increase in awakenings per hour (AWK/h) vs. Controls (C) (p = 0.008). In particular, MoA children showed a reduced CAP rate% (p ≤ 0.001), CAP rate% in S1 (p ≤ 0.001) and CAP rate% in SWS (p = 0.004) vs. C. Moreover, A phases distribution were characterized by a reduction in slow wave components (total number CAP A1%, CAP A1 index) (p ≤ 0.001) and an increase of fast components representation (total number of CAP A2% and CAP A3%) (p < 0.001) in MoA vs. C. Moreover, MoA children showed an increased A1 and A2 mean duration (p ≤ 0.001). Our findings show a reduction of arousability in MoA group and lower NREM lower sleep instability associated with MoA in children.

yearjournalcountryeditionlanguage
2019-08-01Frontiers in Neurology
10.3389/fneur.2019.00932http://europepmc.org/articles/PMC6736572