6533b82ffe1ef96bd1295a8e
RESEARCH PRODUCT
The effects of metal implants on inflammatory and healing processes
Roman TsarykC. James KirkpatrickRonald E. UngerDieter ScharnweberKirsten Peterssubject
Materials scienceMetallurgyWear debrisMetals and AlloysAseptic looseningImplant failureInflammationCondensed Matter PhysicsCorrosionMetalvisual_artMaterials Chemistryvisual_art.visual_art_mediumBiophysicsmedicinePhysical and Theoretical Chemistrymedicine.symptomWound healingdescription
Abstract Metal implants are known for their superior mechanical properties. However, cases of implant failure mainly due to aseptic loosening do occur. The formation of particulate wear debris and corrosion products, such as metal ions and reactive oxygen species, are considered to be crucial factors leading to the failure of metal implants. These metal degradation and corrosion products can induce inflammatory responses, mediated among others by neutrophils, macrophages and endothelial cells. Furthermore, these degradation products may affect blood vessel formation, one of the central processes in wound healing after implantation. Such events can lead to the aseptic loosening of implants culminating in the necessity for revision surgery.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2007-07-01 | International Journal of Materials Research |