Organocatalytic enantioselective functionalization of indoles in the carbocyclic ring with cyclic imines

6533b82ffe1ef96bd1295b66

RESEARCH PRODUCT

Organocatalytic enantioselective functionalization of indoles in the carbocyclic ring with cyclic imines

Arturo Tortosa Carlos Vila José R. Pedro M. Carmen Muñoz Gonzalo Blay

subject

Alkylation 02 engineering and technology Alkylation 010402 general chemistry Ring (chemistry)01 natural sciences Hydroxyindoles Catalysis Ketimines Reaccions químiques chemistry.chemical_compound Materials Chemistry Friedel-Crafts reaction Bifunctional Friedel–Crafts reaction Construction Asymmetric-Synthesis Chemistry Inhibitors Enantioselective synthesis General Chemistry 021001 nanoscience & nanotechnology Combinatorial chemistry 0104 chemical sciences FISICA APLICADA Surface modification 0210 nano-technology Química orgànica Derivatives

description

[EN] An organocatalytic enantioselective functionalization in the carbocyclic ring of indoles with benzoxathiazine 2,2-dioxides is described using a quinine-derived bifunctional organocatalyst. This aza-Friedel-Crafts reaction provides 4-indolyl, 5-indolyl and 7-indolyl sulfamidate derivatives in good yields (up to 99%) and with moderate to high enantioselectivities (up to 86% ee).

year	journal	country	edition	language
2019-01-07

10.1039/c8nj05577g https://doi.org/10.1039/C8NJ05577G

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