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RESEARCH PRODUCT
Electroencephalographic Abnormalities in Autism Spectrum Disorder: Characteristics and Therapeutic Implications.
Luigi VetriLucia ParisiFrancesco PrecenzanoClaudia SantoroIlaria BitettiGiovanni MessinaGrazia Maria Giovanna PastorinoFrancesca Felicia OpertoMaria Cristina RisoleoMaria Cristina RisoleoValentina LanzaraMaria RubertoRosa Marottasubject
Malemedicine.medical_specialtyMedicine (General)Autism Spectrum Disorderautism spectrum disordersPopulationEpiphenomenonDysfunctional familyChild Behavior DisordersReviewAudiologybehavioral disciplines and activities03 medical and health sciencesEpilepsy0302 clinical medicineBorderline intellectual functioningR5-920mental disordersmedicineHumansCognitive DysfunctioneducationChildSubclinical infectioneducation.field_of_studyEpilepsyEvidence-Based MedicineEpileptogenic abnormalitiebusiness.industryepileptogenic abnormalitiesElectroencephalographyGeneral Medicineelectroencephalogrammedicine.diseaseSettore MED/39 - Neuropsichiatria Infantile030227 psychiatryAutism spectrum disorderAutismAnticonvulsantsFemaleAutism spectrum disorders Electroencephalogram Epilepsy Epileptogenic abnormalities Non-epileptiform abnormalitiesbusinessnon-epileptiform abnormalities030217 neurology & neurosurgerydescription
A large body of literature reports the higher prevalence of epilepsy in subjects with Autism Spectrum Disorder (ASD) compared to the general population. Similarly, several studies report an increased rate of Subclinical Electroencephalographic Abnormalities (SEAs) in seizure-free patients with ASD rather than healthy controls, although with varying percentages. SEAs include both several epileptiform discharges and different non-epileptiform electroencephalographic abnormalities. They are more frequently associated with lower intellectual functioning, more serious dysfunctional behaviors, and they are often sign of severer forms of autism. However, SEAs clinical implications remain controversial, and they could represent an epiphenomenon of the neurochemical alterations of autism etiology. This paper provides an overview of the major research findings with two main purposes: to better delineate the state-of-the-art about EEG abnormalities in ASD and to find evidence for or against appropriateness of SEAs pharmacological treatment in ASD.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-01-01 | Medicina (Kaunas, Lithuania) |