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RESEARCH PRODUCT
The latent structure of the functional dyspepsia symptom complex: A taxometric analysis
Michael WitthöftJan TackMarta WalentynowiczO. Van Den BerghFabian JasperL. Van Oudenhovesubject
AdultMaleAbdominal painAdolescentPhysiologyEpigastric painYoung Adult03 medical and health sciences0302 clinical medicineSurveys and QuestionnairesmedicineHumansDyspepsiaLatent structureAgedAged 80 and overTertiary HealthcareEndocrine and Autonomic Systemsbusiness.industrySingle factorGastroenterologyNauseaMiddle AgedClassificationPostprandial Periodmedicine.diseaseRome iiiConfirmatory factor analysisAbdominal PainDistress030220 oncology & carcinogenesisFemale030211 gastroenterology & hepatologymedicine.symptombusinessSomatizationClinical psychologydescription
OBJECTIVES: Rome III introduced a subdivision of functional dyspepsia (FD) into postprandial distress syndrome and epigastric pain syndrome, characterized by early satiation/postprandial fullness, and epigastric pain/burning, respectively. However, evidence on their degree of overlap is mixed. We aimed to investigate the latent structure of FD to test whether distinguishable symptom-based subgroups exist. METHODS: Consecutive tertiary care Rome II FD patients completed the dyspepsia symptom severity scale. Confirmatory factor analysis (CFA) was used to compare the fit of a single factor model, a correlated three-factor model based on Rome III subgroups and a bifactor model consisting of a general FD factor and orthogonal subgroup factors. Taxometric analyses were subsequently used to investigate the latent structure of FD. KEY RESULTS: Nine hundred and fifty-seven FD patients (71.1% women, age 41 ± 14.8) participated. In CFA, the bifactor model yielded a significantly better fit than the two other models (χ² difference tests both p 0.05). Taxometric analyses supported a dimensional structure of FD (all CCFI<0.38). CONCLUSIONS AND INFERENCES: We found a dimensional rather than categorical latent structure of the FD symptom complex in tertiary care. A combination of a general dyspepsia symptom reporting factor, which was associated with somatization, and symptom-specific factors reflecting the Rome III subdivision fitted the data best. This has implications for classification, pathophysiology, and treatment of FD. ispartof: Neurogastroenterology and Motility vol:28 issue:7 pages:985-993 ispartof: location:England status: published
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-06-24 |