6533b830fe1ef96bd129664a

RESEARCH PRODUCT

Inorganic Nitrate Therapy Improves Doxorubicin-Induced Cardiomyopathy

Tommaso GoriThomas MünzelAndreas Daiber

subject

Cardioprotectionmedicine.medical_specialtyCardiotoxicityAnthracyclinebusiness.industryAntineoplastic AntibioticCancerDilated cardiomyopathyPharmacologymedicine.diseasecarbohydrates (lipids)Internal medicineHeart failurepolycyclic compoundsmedicineCardiologyDoxorubicinbusinessCardiology and Cardiovascular Medicinemedicine.drug

description

The anthracycline doxorubicin (DOX) is a potent and effective antineoplastic antibiotic agent widely used in the treatment of a broad range of forms of cancer. The clinical use of DOX is limited by cardiotoxicity, which increases dose dependently and may lead to dilated cardiomyopathy and clinical

10.1016/j.jacc.2011.02.019http://dx.doi.org/10.1016/j.jacc.2011.02.019