6533b830fe1ef96bd129689f

RESEARCH PRODUCT

Three cases of neonatal herpes simplex virus infection presenting as fulminant hepatitis

W. MannhardtV. TalebzadehS. HassamS. SuterNadine BenadorChristian BraeggerS. FanconiD. SchranzJ. Cox

subject

MaleTime FactorsHepatitis Viral HumanvirusesAcyclovirDiseaseHSL and HSVmedicine.disease_causeDiagnosis DifferentialNeonatal herpes simplex virus infectionNecrosisLiver tissuemedicineHumansSimplexvirusFulminant hepatitisHepatitisHsv infectionbusiness.industryInfant NewbornHerpes Simplexmedicine.diseaseVirologyHerpes simplex virusAcute DiseasePediatrics Perinatology and Child HealthImmunologyFemalebusiness

description

We report three cases of neonatal herpes simplex virus (HSV) infection presenting as fulminant hepatitis. None of the patients had clear risk factors for HSV infection and they all died. Antiviral treatment for HSV is currently available but must be administered early in the course of the disease before irreversible liver tissue damage is present. Since the diagnosis may be difficult to establish, we wish to draw the attention of clinicians to the presentation of neonatal HSV infection and suggest that in such cases viral cultures, including culture of liver tissue, should be obtained early and antiviral treatment administered while awaiting the culture results.

yearjournalcountryeditionlanguage
1990-05-01European Journal of Pediatrics
https://doi.org/10.1007/bf01957691