6533b830fe1ef96bd129706e
RESEARCH PRODUCT
Cellular Uptake of DNA Block Copolymer Micelles with Different Shapes
N. Ceren AlemdarogluAndreas HerrmannPeter LangguthFikri E. Alemdaroglusubject
Polymers and PlasticsmicellesOligonucleotidemedia_common.quotation_subjectOrganic Chemistrycellular uptakeNanoparticleCaco-2DNAMicellechemistry.chemical_compoundchemistryCritical micelle concentrationMaterials ChemistryBiophysicsCopolymerOrganic chemistrynanoparticlesamphiphilic polymerInternalizationDrug carrierhybridizationDNAmedia_commondescription
The cellular uptake of DNA block copolymer micelles composed of DNA-b-PPO in Caco-2 cells was studied. In particular it was investigated if the shape of micelle aggregates influences the internalization. Rod-like polymeric particles were taken up 12 times more efficiently than their spherical counter parts although they were composed of the same constituents. Furthermore, it was observed that internalization of all the micelle systems was more efficient than the pristine DNA controls. A cytotoxicity assay proved the non-toxic nature of DNA-b-PPO micelle aggregates.
year | journal | country | edition | language |
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2008-02-18 | Macromolecular Rapid Communications |