0000000000380664

AUTHOR

N. Ceren Alemdaroglu

showing 3 related works from this author

Inhibition of Folic Acid Uptake by Catechins and Tea Extracts in Caco-2 Cells

2006

In this present study it was aimed to determine whether the catechins contained in green tea and the whole extracts of Camellia sinensis (Theaceae) inhibit the uptake of folic acid by Caco-2 cell monolayers. Our results indicate that (-)-epigallocatechin 3-gallate (EGCG) and (-)-epicatechin 3-gallate (ECG) inhibit cellular folic acid uptake with IC50 values of 34.8 micromol/L and 30.8 micromol/L, respectively. Furthermore, green and black tea extracts were also found to inhibit folic acid uptake with IC50 values of approximately 7.5 and 3.6 mg/mL, respectively. According to these results, simultaneous intake of tea and folic acid may inhibit intestinal folic acid absorption. The consequence…

VitaminFlavonoidPharmaceutical SciencePharmacognosyAntioxidantsCamellia sinensisCatechinAnalytical Chemistrylaw.inventionInhibitory Concentration 50chemistry.chemical_compoundFolic AcidlawDrug DiscoveryHumansPhenolsTheaceaeFood sciencePharmacologychemistry.chemical_classificationbiologyPlant ExtractsOrganic Chemistryfood and beveragesCatechinbiology.organism_classificationIntestinal AbsorptionComplementary and alternative medicinechemistryBiochemistryPolyphenolMolecular MedicineCaco-2 CellsPhytotherapyPhytotherapyPlanta Medica
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Influence of green and black tea on folic acid pharmacokinetics in healthy volunteers: potential risk of diminished folic acid bioavailability

2008

Previous in vitro studies using Caco-2 cell monolayers suggested a possible interaction between green and black tea and folic acid at the level of intestinal absorption. The main purpose of the present study was to investigate a possible pharmacokinetic interaction between tea and folic acid in healthy volunteers. In an open-labeled randomized cross-over study, the pharmacokinetic interaction between tea and folic acid (0.4 mg and 5 mg) was investigated in healthy volunteers. Water was used as the reference drink. Subjects ingested 0.4 mg folic acid tablets with water, green or black tea (0.3 g extract/250 ml) or 5 mg folic acid tablets with water or green tea (0.3 g extract/250 ml). Blood …

AdultMaleBiological AvailabilityPharmaceutical SciencePharmacologyIntestinal absorptionFood-Drug InteractionsFolic AcidPharmacokineticsIn vivoHumansPharmacology (medical)Black teaImmunoassayPharmacologyCross-Over StudiesDose-Response Relationship DrugTeaChemistryfood and beveragesGeneral MedicineMiddle AgedCrossover studyBioavailabilityDose–response relationshipFolic acidArea Under CurveLuminescent MeasurementsVitamin B ComplexFemaleBiopharmaceutics & Drug Disposition
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Cellular Uptake of DNA Block Copolymer Micelles with Different Shapes

2008

The cellular uptake of DNA block copolymer micelles composed of DNA-b-PPO in Caco-2 cells was studied. In particular it was investigated if the shape of micelle aggregates influences the internalization. Rod-like polymeric particles were taken up 12 times more efficiently than their spherical counter parts although they were composed of the same constituents. Furthermore, it was observed that internalization of all the micelle systems was more efficient than the pristine DNA controls. A cytotoxicity assay proved the non-toxic nature of DNA-b-PPO micelle aggregates.

Polymers and PlasticsmicellesOligonucleotidemedia_common.quotation_subjectOrganic Chemistrycellular uptakeNanoparticleCaco-2DNAMicellechemistry.chemical_compoundchemistryCritical micelle concentrationMaterials ChemistryBiophysicsCopolymerOrganic chemistrynanoparticlesamphiphilic polymerInternalizationDrug carrierhybridizationDNAmedia_commonMacromolecular Rapid Communications
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