6533b7dbfe1ef96bd1270c37
RESEARCH PRODUCT
Inhibition of Folic Acid Uptake by Catechins and Tea Extracts in Caco-2 Cells
N. Ceren AlemdarogluEllen I. ClossHildegard Spahn-langguthPeter LangguthSiegfried WolfframJean-paul Boisselsubject
VitaminFlavonoidPharmaceutical SciencePharmacognosyAntioxidantsCamellia sinensisCatechinAnalytical Chemistrylaw.inventionInhibitory Concentration 50chemistry.chemical_compoundFolic AcidlawDrug DiscoveryHumansPhenolsTheaceaeFood sciencePharmacologychemistry.chemical_classificationbiologyPlant ExtractsOrganic Chemistryfood and beveragesCatechinbiology.organism_classificationIntestinal AbsorptionComplementary and alternative medicinechemistryBiochemistryPolyphenolMolecular MedicineCaco-2 CellsPhytotherapyPhytotherapydescription
In this present study it was aimed to determine whether the catechins contained in green tea and the whole extracts of Camellia sinensis (Theaceae) inhibit the uptake of folic acid by Caco-2 cell monolayers. Our results indicate that (-)-epigallocatechin 3-gallate (EGCG) and (-)-epicatechin 3-gallate (ECG) inhibit cellular folic acid uptake with IC50 values of 34.8 micromol/L and 30.8 micromol/L, respectively. Furthermore, green and black tea extracts were also found to inhibit folic acid uptake with IC50 values of approximately 7.5 and 3.6 mg/mL, respectively. According to these results, simultaneous intake of tea and folic acid may inhibit intestinal folic acid absorption. The consequences with respect to the folate status of the body will need to be examined in vivo.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2006-11-21 | Planta Medica |