Simple two-step synthesis of 2,4-disubstituted pyrroles and 3,5-disubstituted pyrrole-2-carbonitriles from enones

6533b830fe1ef96bd1297167

RESEARCH PRODUCT

Simple two-step synthesis of 2,4-disubstituted pyrroles and 3,5-disubstituted pyrrole-2-carbonitriles from enones

Christine Wiebe Dorota Ferenc Till Opatz Murat Kucukdisli Marcel Heinz

subject

heterocycles cyclization Organic Chemistry Two step α-aminonitriles Combinatorial chemistry Full Research Paper microwave-assisted synthesis lcsh:QD241-441 Chemistry chemistry.chemical_compound chemistry lcsh:Organic chemistry Simple (abstract algebra)pyrroles Aminoacetonitrile lcsh:Q lcsh:Science Pyrrole

description

The cyclocondensation of enones with aminoacetonitrile furnishes 3,4-dihydro-2H-pyrrole-2-carbonitriles which can be readily converted to 2,4-disubstituted pyrroles by microwave-induced dehydrocyanation. Alternatively, oxidation of the intermediates produces 3,5-disubstituted pyrrole-2-carbonitriles.

year	journal	country	edition	language
2014-02-01	Beilstein Journal of Organic Chemistry

10.3762/bjoc.10.44 https://doaj.org/article/3ee2c665dcdd4d1b809333b72e15fbdd

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