A comparison of semiparametric approaches to evaluate composite endpoints in heart failure trials

6533b830fe1ef96bd129717d

RESEARCH PRODUCT

A comparison of semiparametric approaches to evaluate composite endpoints in heart failure trials

Tobias Mütze Antje Jahn-eimermacher Gerrit Toenges

subject

Statistics and Probability medicine.medical_specialty Epidemiology 610 Medizin heart failure least false parameter Positive correlation joint frailty model Correlation LWYY model 610 Medical sciences Internal medicine Multicenter trial medicine Humans Treatment effect Fraction (mathematics)proportional rates models Proportional Hazards Models Proportional hazards model business.industry 610 Medical sciences; Medicine medicine.disease composite endpoint Recurrent event Treatment Outcome ddc: 610 recurrent events Heart failure Cardiology business

description

In heart failure trials efficacy is usually proven by a composite endpoint including cardiovascular death (CVD) and recurrent heart failure hospitalisations (HFH), evaluated with time-to-first-event analysis based on a Cox model. As a considerable fraction of events is ignored that way, recurrent event[for full text, please go to the a.m. URL]

year	journal	country	edition	language
2021-02-26

https://dx.doi.org/10.3205/20gmds033

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