6533b830fe1ef96bd1297191

RESEARCH PRODUCT

Matrix metalloproteinases 2 and 9, and extracellular matrix in Kaposi's sarcoma

Maria Rita BongiornoSpyridoula DoukakiMario AricoGiuseppe Ferro

subject

Skin NeoplasmsAngiogenesisDermatologyMatrix metalloproteinasemedicine.disease_causeBasement MembraneExtracellular matrixCell Movementmatrix metalloproteinase-9Settore MED/35 - Malattie Cutanee E VenereemedicineHumansSarcoma KaposiKaposi's sarcomaBasement membraneNeovascularization Pathologicbusiness.industryGeneral Medicinemedicine.diseaseVirologyExtracellular Matrixmedicine.anatomical_structureMatrix Metalloproteinase 9Invasive growthsarcoma of KaposiCancer researchMatrix Metalloproteinase 2SarcomaCarcinogenesisbusinessmatrix metalloproteinase- 2

description

Matrix metalloproteinases (MMPs) are associated with Kaposi's sarcoma (KS) tumorigenesis and may contribute to the mechanism of KS invasive growth. To date, only a few MMPs have been studied in KS lesions, and exactly which MMPs are involved in KS development and progression remains unanswered. However, MMPs 2 and 9 have been associated with different phases of angiogenesis, but their role in the proteolytic modification of the extracellular matrix has not been investigated. The results of this study confirm that MMPs, specifically MMP-2 and MMP-9, can contribute to angiogenesis by disrupting the vessel basement membrane and other extracellular matrix barriers, and enabling endothelial cells migration through the surrounding tissues.

yearjournalcountryeditionlanguage
2010-03-01Dermatologic Therapy
https://doi.org/10.1111/j.1529-8019.2010.01297.x