6533b830fe1ef96bd1297331
RESEARCH PRODUCT
The Role of Adrenoceptors in the Retina
Subao JiangYue RuanTobias BöhmerAdrian Gerickesubject
0301 basic medicineretinaAdrenergic receptorgenetic structuresCentral nervous systemReviewα<sub>1</sub>-ARBiology03 medical and health scienceschemistry.chemical_compound0302 clinical medicineRetinal DiseasesmedicinedistributionAnimalsHumansα1-ARlcsh:QH301-705.5NeuronsRetinafunctionBinding Sitesα<sub>2</sub>-ARNeurodegenerationRetinalNeurodegenerative DiseasesGeneral Medicinemedicine.diseaseeye diseasesReceptors Adrenergic030104 developmental biologymedicine.anatomical_structurechemistrylcsh:Biology (General)β-ARNeuroscience030217 neurology & neurosurgeryα2-ARdescription
The retina is a part of the central nervous system, a thin multilayer with neuronal lamination, responsible for detecting, preprocessing, and sending visual information to the brain. Many retinal diseases are characterized by hemodynamic perturbations and neurodegeneration leading to vision loss and reduced quality of life. Since catecholamines and respective bindings sites have been characterized in the retina, we systematically reviewed the literature with regard to retinal expression, distribution and function of alpha1 (α1)-, alpha2 (α2)-, and beta (β)-adrenoceptors (ARs). Moreover, we discuss the role of the individual adrenoceptors as targets for the treatment of retinal diseases.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-12-01 | Cells |