6533b830fe1ef96bd12978ac
RESEARCH PRODUCT
A stiff extracellular matrix is associated with malignancy in peripheral neuroblastic tumors
Ana P. BerbegallIrene TadeoSamuel NavarroRosa NogueraVictoria Castelsubject
0301 basic medicineReticular fiberPathologymedicine.medical_specialtybusiness.industryHematologyMatrix (biology)Malignancymedicine.diseaseNeuroblastic TumorPeripheralExtracellular matrix03 medical and health sciences030104 developmental biology0302 clinical medicineOncology030220 oncology & carcinogenesisNeuroblastomaPediatrics Perinatology and Child HealthReticular connective tissuemedicinebusinessdescription
Purpose and objective Improved prognosis for patients with peripheral neuroblastic tumors (PNB) depends on enhanced pretreatment risk stratification combined with research into new therapeutic targets. This study investigated the potential contribution of extracellular matrix (ECM) elements toward this endeavor. Methods We characterized certain elements such as reticulin fibers, collagen type I fibers, and elastic fibers by digital pathology in almost 400 untreated PNB. Results A reticular and poorly porous ECM was identified in neuroblastomas (NBs) from patients with clinical and biological features associated with poor prognosis compared with a loose and permeable matrix found in NBs of the favorable cohort. Conclusions Aggressiveness patterns of ECM can be accurately determined by morphometric tools and could become candidate elements for novel therapies.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-01-25 | Pediatric Blood & Cancer |