6533b830fe1ef96bd1297936

RESEARCH PRODUCT

“Small Volume Resuscitation” as Treatment of Cerebral Blood Flow Disturbances and Increased ICP in Trauma and Ischemia

C. ObertU. StreckerT. MainkaAxel HeimannOliver Kempski

subject

medicine.medical_specialtybusiness.industryIschemiavirus diseasesmedicine.diseasedigestive system diseasesHypertonic salineCerebral circulationCerebral blood flowSomatosensory evoked potentialInternal medicineShock (circulatory)medicineIntravascular volume statusCardiologymedicine.symptombusinessIntracranial pressure

description

“Small volume resuscitation” (SVR) is a promising concept for the treatment of shock and trauma patients. SVR utilizes the fast infusion of a small volume of hypertonic saline to mobilize intraendothelial and parenchymal water to expand and restitute intravascular volume. Therefore it seems warranted to also consider SVR for the treatment of disturbances of the cerebral circulation and of increased intracranial pressure (ICP). The current study uses a rabbit model of global cerebral ischemia combined with mild hemorrhage to test SVR. Somatosensory evoked potentials (SEPs) serve as a short-term outcome parameter. The data demonstrate a beneficial effect on ICP, a better reperfusion, and an improved recovery of SEPs after treatment with hypertonic/hyperoncotic saline/hydroxyethylstarch as compared to volume replacement with starch or blood.

yearjournalcountryeditionlanguage
1996-01-01
https://doi.org/10.1007/978-3-7091-9465-2_20