6533b830fe1ef96bd1297a8f

RESEARCH PRODUCT

Redox Biochemistry of the Genetic Code.

Bernd Moosmann

subject

chemistry.chemical_classification0303 health sciencesModels GeneticChemistryProteinsGenetic codeBiochemistryRedoxHalophileEnzyme catalysisAmino acidEvolution Molecular03 medical and health sciences0302 clinical medicineBiochemistryAbiogenesisGenetic CodeProtein foldingAmino AcidsMolecular BiologyOxidation-Reduction030217 neurology & neurosurgery030304 developmental biology

description

New findings on the chemistry of the amino acids, their role in protein folding, and their sequential primordial introduction have uncovered concealed causalities in genetic code evolution. The genetically encoded amino acids successively provided (i) membrane anchors, (ii) halophilic protein folds, (iii) mesophilic protein folds, (iv) metal ligation, and (v) antioxidation.

10.1016/j.tibs.2020.10.008https://pubmed.ncbi.nlm.nih.gov/33250285