6533b830fe1ef96bd1297af3
RESEARCH PRODUCT
Variations in central corneal thickness during the menstrual cycle in women.
Giuseppe Giuffre'Fabio FiorinoGaetano LodatoDaniele Morreale BubellaL Di RosaDm Budellasubject
Adultmedicine.medical_specialtyVisual acuitymedia_common.quotation_subjectVisual AcuityReproductive ageCorneal thickness menstrual cycleCorneaReference ValuesMedicineHumansBody Weights and MeasuresOvulationMenstrual cycleMenstrual Cyclemedia_commonUltrasonographySettore MED/30 - Malattie Apparato Visivobusiness.industryObstetricsFollow up studiesEstrogensSettore MED/40 - Ginecologia E OstetriciaOphthalmologyReference valuesFemalesense organsUltrasonographymedicine.symptombusinessFollow-Up Studiesdescription
PURPOSE: We report changes in the central corneal thickness during various phases of the menstrual cycle. METHODS: We recruited 16 healthy women of reproductive age and measured the central corneal thickness at 3 points in their menstrual cycle, beginning on days 1 to 3 and again at ovulation and at the end of the cycle (days 27-32). Ovulation was determined with a test that determines the peak of luteinizing hormone in the urine. RESULTS: We found that the central cornea was thinnest at the beginning of the cycle (mean = 536 microm). Corneal thickness increased at ovulation (mean = 549 microm) and at the end of the cycle (mean = 559 microm). The difference in corneal thickness was statistically significant at ovulation (P = 0.003) and the end of cycle (P = 0.001) compared with values at the beginning of the cycle. CONCLUSION: The central corneal thickness changes during the menstrual cycle; the cornea is thinnest at the beginning of the cycle and thickest at the end. These changes could be secondary to hormonal influences; estrogen receptors can be found in human corneas, suggesting that estrogen may have a role in corneal physiology.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2007-02-01 | Cornea |