6533b830fe1ef96bd1297b68

RESEARCH PRODUCT

Halloysite Nanotubes Coated by Chitosan for the Controlled Release of Khellin

Stefana MiliotoLorenzo LisuzzoGiuseppe CavallaroGiuseppe Lazzara

subject

khellinAqueous solutionMaterials scienceKhellinPolymers and Plasticsrelease propertieshalloysite nanotubesthermogravimetryGeneral Chemistryengineering.materialHalloysiteControlled releaseArticleNanomaterialslcsh:QD241-441ChitosanContact anglechemistry.chemical_compoundlcsh:Organic chemistrychemistryChemical engineeringengineeringSurface chargechitosan

description

In this work, we have developed a novel strategy to prepare hybrid nanostructures with controlled release properties towards khellin by exploiting the electrostatic interactions between chitosan and halloysite nanotubes (HNT). Firstly, khellin was loaded into the HNT lumen by the vacuum-assisted procedure. The drug confinement within the halloysite cavity has been proved by water contact angle experiments on the HNT/khellin tablets. Therefore, the loaded nanotubes were coated with chitosan as a consequence of the attractions between the cationic biopolymer and the halloysite outer surface, which is negatively charged in a wide pH range. The effect of the ionic strength of the aqueous medium on the coating efficiency of the clay nanotubes was investigated. The surface charge properties of HNT/khellin and chitosan/HNT/khellin nanomaterials were determined by &zeta

yearjournalcountryeditionlanguage
2020-08-07Polymers
https://doi.org/10.3390/polym12081766