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RESEARCH PRODUCT
Neuromuscular electrophysiological disorders and muscle atrophy in mechanically-ventilated traumatic brain injury patients: New insights from a prospective observational study
Priscilla Flávia De MeloHedian GomesKarina Livino De CarvalhoNicolas BabaultJoão Luiz Quagliotti DuriganLuciana Marques VieiraGerson CiprianoVinicius MaldanerPaulo Eugênio SilvaPaulo Eugênio Silvasubject
AdultMaleTraumatic brain injuryCritical Illnessmedicine.medical_treatmentNeuromuscular disorderCritical Care and Intensive Care MedicineBicepsNeuromuscular electrical stimulationlaw.invention03 medical and health sciences0302 clinical medicinelawChronaxieBrain Injuries TraumaticmedicineHumansProspective StudiesCritical illness polyneuropathyMuscle SkeletalProspective cohort studyMechanical ventilationAnalysis of VarianceRehabilitationIntensive care unit-acquired weaknessbusiness.industryRehabilitation030208 emergency & critical care medicineNeuromuscular DiseasesMiddle Agedmedicine.diseaseRespiration ArtificialIntensive care unitMuscle atrophy3. Good healthIntensive Care UnitsMuscular Atrophy[ SDV.NEU ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]AnesthesiaFemale[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]medicine.symptombusiness[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology030217 neurology & neurosurgeryCritical illness polyneuropathydescription
International audience; Erratum inCorrigendum to "Neuromuscular electrophysiological disorders and muscle atrophy in mechanically-ventilated traumatic brain injury patients: New insights from a prospective observational study" [J Crit Care 44 (2018) 87-94]. [J Crit Care. 2019]AbstractPURPOSE:It is unclear whether the muscular changes in mechanically-ventilated traumatic brain injury patients (TBI) are only associated with disuse or additionally to neuromuscular electrophysiological disorders (NED). The correlation between muscle atrophy and NED may affect functional outcomes and rehabilitation programs significantly.MATERIAL AND METHODS:An observational study was performed to investigate the presence of NED and muscle atrophy in TBI patients undergoing mechanical ventilation. NED was diagnosed by the stimulus electrodiagnosis test when chronaxie was ≥1000μs. The muscle structure (thickness and echogenicity) was assessed by B-mode ultrasound. Tibialis anterior (TA), rectus femoris (RF), and biceps brachialis (BB) muscles were analyzed. Patients were followed from the first day of admission in the intensive care unit (ICU) to the fourteenth day.RESULTS:Twenty-two patients were analyzed. An increase of 48% in NED from day 1 to day 14 was detected in TA (p=0.004). All muscles presented a significant decrease in thickness (~18%, p<0.05), but echogenicity increased only in TA (19%), p<0.01 and RF (23%), p<0.01.CONCLUSIONS:Mechanically-ventilated patients with TBI developed NED in addition to changes in muscle structure during their stay in the ICU.Copyright © 2017 Elsevier Inc. All rights reserved.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-04-01 |