6533b831fe1ef96bd129849b
RESEARCH PRODUCT
Process parameters of microsphere preparation based on propylene carbonate emulsion-precursors.
Alf LamprechtAlf LamprechtDaris Grizićsubject
Materials sciencePolymersSurface PropertiesChemistry PharmaceuticalDrug CompoundingPharmaceutical ScienceBioengineering02 engineering and technologyPolypropylenes030226 pharmacology & pharmacyMicrosphere03 medical and health scienceschemistry.chemical_compound0302 clinical medicineColloid and Surface ChemistryLactic AcidPhysical and Theoretical ChemistryParticle SizeDrug CarriersCalorimetry Differential ScanningViscosityOrganic Chemistry021001 nanoscience & nanotechnologyMicrospheresPLGADrug LiberationchemistryChemical engineeringSolubilityCelecoxibScientific methodPropylene carbonateEmulsionMicroscopy Electron ScanningSolventsEmulsions0210 nano-technologyPolyglycolic Aciddescription
This study aimed for a detailed understanding of the impact of different process parameters involved during celecoxib-loaded microsphere preparation based on propylene carbonate emulsion-precursors.Microspheres were prepared by a modified emulsification-solvent extraction method. Performed investigations included polymer solubility and viscosity, microsphere size, morphology and stability, propylene carbonate content as well as celecoxib solid state, content and release.Rough-walled round microspheres with sizes between 21 µm and 122 µm and an internal sponge-like structure filled with residual propylene carbonate (content between 1.9 ± 0.1% and 6.7 ± 0.5% w/w) were obtained. Encapsulation efficiencies varied between 28.3 ± 0.1% and 66.8 ± 1.0%. The release rates were affected by the polymer concentration, the emulsion phase ratio and the residual propylene carbonate content (tThis study identified the most relevant process parameters for this new preparation method for the model drug celecoxib.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-09-16 | Journal of microencapsulation |