6533b831fe1ef96bd1298ea2
RESEARCH PRODUCT
Histologically benign metastatic meningioma: morphological and cytogenetic study. Case report.
Fernando TalamantesConcha López-ginésPedro RoldánJosé BarberáMiguel Pérez-baceteMiguel Cerdá-nicolássubject
Malemedicine.medical_specialtyPathologyMonosomyLung NeoplasmsMetastasisMeningiomaMeningeal NeoplasmsMedicineHumansAgedmedicine.diagnostic_testbusiness.industrySplenic NeoplasmsMetastatic MeningiomaLiver NeoplasmsCytogeneticsmedicine.diseaseMagnetic Resonance ImagingKidney NeoplasmsBenign MeningiomaCytogenetic AnalysisbusinessMeningiomaChromosome 22Fluorescence in situ hybridizationdescription
✓ The authors report on a 75-year-old man with histologically benign fibroblastic meningioma metastasizing to the lung, liver, spleen, and kidney. The original tumor exhibited a complex karyotype involving different structural and numerical anomalies associated with monosomy of chromosome 22. The implication of chromosome 1p36 was confirmed by fluorescence in situ hybridization in most interphase nuclei. Metastases occurred 4 months after incomplete resection with prior therapeutic embolization. The recurrent tumor in turn displayed anaplastic features and an increased Ki-67 labeling index. Genetic alterations in such morphologically benign meningiomas have been implicated in the malignant development and progression of these tumors.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2003-01-28 | Journal of neurosurgery |