6533b831fe1ef96bd129910f

RESEARCH PRODUCT

Liver failure caused by light chain deposition disease associated with multiple myeloma.

Elia Muñoz VicenteArmando V. Mena-duranGonzalo Pareja LlorensJosé Sanchis Cervera

subject

MalePathologymedicine.medical_specialtyEncephalopathyParaproteinemiasCholestasis IntrahepaticImmunoglobulin light chainLight chain deposition diseaseImmunoglobulin kappa-ChainsFatal OutcomeCholestasisInternal MedicineMedicineHumansMultiple myelomaAgedAged 80 and overmedicine.diagnostic_testbusiness.industryGeneral MedicineJaundiceLiver Failure Acutemedicine.diseaseLiver biopsyHepatic Encephalopathymedicine.symptomComplicationbusinessMultiple Myeloma

description

Acute liver failure is an unusual complication in multiple myeloma. Here, we report a case of multiple myeloma with light chain deposition disease (LCDD) that presented with progressive jaundice due to intrahepatic cholestasis. Diagnosis was made after liver biopsy that showed deposition of kappa light chains occupying perisinusoidal spaces. The patient developed encephalopathy and liver failure and died despite prompt initiation of dexamethasone therapy. The current prognosis of multiple myeloma patients with liver failure due to LCDD is dismal. New therapeutic strategies might improve this condition.

yearjournalcountryeditionlanguage
2012-04-03Internal medicine (Tokyo, Japan)
10.2169/internalmedicine.51.6510https://pubmed.ncbi.nlm.nih.gov/22466837