6533b831fe1ef96bd12998d4

RESEARCH PRODUCT

Quantification of resting myocardial blood flow in a pig model of acute ischemia based on first-pass MRI

Thorsten GumbrichAndrea KargGeorg HorstickMelanie SchmittWolfgang SchreiberNico HoffmannNico AbegunewardeneSteffen E. Petersen

subject

Gadolinium DTPAmedicine.medical_specialtyMyocardial ischemiaSwineMyocardial IschemiaContrast MediaStatistics NonparametricAcute ischemiaCoronary artery diseaseFluorescent microspheresCoronary CirculationInternal medicinemedicineAnimalsRadiology Nuclear Medicine and imagingFirst passbusiness.industryPig modelBlood flowmedicine.diseaseMagnetic Resonance ImagingDisease Models AnimalAcute DiseaseCardiologybusinessPerfusioncirculatory and respiratory physiology

description

Qualitative and semiquantitative contrast-enhanced (CE) dynamic perfusion MRI techniques are established as noninvasive diagnostic means of assessing coronary artery disease. However, to date quantification of myocardial blood flow (MBF) has not reached the same acceptance as MBF quantification with nuclear techniques. To validate quantification of MBF at rest using the extracellular contrast agent (CA) Gd-DTPA, we performed an animal study in a pig model of acute myocardial ischemia. We quantified MBF from MRI data with a mathematical model (MMID4) of the underlying vasculature. These MBF results were subsequently compared with the results from fluorescent microspheres. The study showed a correlation of r = 0.66 between MBF estimates obtained with MRI and those obtained with fluorescent microspheres. The correlation for ischemic and nonischemic myocardium was r = 0.86 and r = 0.47, respectively. In conclusion, quantification of resting MBF using MMID4 is a valid method under conditions of acute myocardial ischemia.

yearjournalcountryeditionlanguage
2005-04-22Magnetic Resonance in Medicine
https://doi.org/10.1002/mrm.20457