6533b831fe1ef96bd129999f
RESEARCH PRODUCT
DNA-Ploidy, Morphometric-Stereological and P-Glycoprotein Study of Superficial Bladder Carcinomas
F. Martinez-diazM. C. Sanchez-fernandez De SevillaM. Perez-baceteB. Fenollosa-entrenaAntonio Llombart-boschManuel Gil-salomL Morell-quadrenyI. Iborra-juansubject
MalePathologymedicine.medical_specialtyUrologyCellPopulationAneuploidyNewly diagnosedBiomarkers TumormedicineHumansIn patientATP Binding Cassette Transporter Subfamily B Member 1educationDna ploidyP-glycoproteineducation.field_of_studyMembrane GlycoproteinsPloidiesbiologybusiness.industryDNA Neoplasmmedicine.diseaseNeoplasm Proteinsmedicine.anatomical_structureUrinary Bladder Neoplasmsbiology.proteinFemalePloidybusinessFollow-Up Studiesdescription
We carried out a DNA-ploidy, morphometric-stereologic and P-glycoprotein study on 40 newly diagnosed superficial bladder cancer patients (G1-G2), correlating the results with histological grade and clinical outcome. Variations in the number of patients who present recurrences, progression or remain tumor-free during the whole follow-up period (at least 5 years) were not significant when related to nuclear size, proliferative diploid index, presence of aneuploidy and expression of P-glycoprotein. It is striking how the majority of disease-free subjects showed a proliferative diploid index higher than 10%. Moreover, 3 of them presented an aneuploid cell population. In our study, only histological grade showed a significant discriminatory level in terms of progression versus no progression in patients with superficial bladder cancer.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1992-01-01 | European Urology |