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RESEARCH PRODUCT

Urothelial Leukoplakia: New Aspects of Etiology and Therapy

J.w. ThueroffH.j. RumpeltStefan C. Mueller

subject

AdultPathologymedicine.medical_specialtybusiness.industryUrologyUrinary systemUrinary BladderMiddle Agedmedicine.diseaseEpitheliumEpitheliumSquamous metaplasiaMicroscopy ElectronBasal (phylogenetics)medicine.anatomical_structureUrinary Bladder NeoplasmsEtiologyHumansMedicineTrigone of urinary bladderFemalebusinessPathologicalLeukoplakiaLeukoplakia

description

AbstractWe describe 3 women in 1 family who had systemic urothelial leukoplakia with no underlying pathological condition of the urinary tract. Irritative clinical symptoms resolved, and the macroscopic and microscopic appearance improved after 6 months of therapy with sodium pentosan-polysulfate. Electron microscopy showed special cells in the basal layer of the cornified squamous epithelium that also have been found in the trigone of women with so-called squamous metaplasia. Their similarity to Merkel’s cells of the skin supports the theory that ectodermal cells are misplaced during embryogenesis. Genetic factors and sex hormones seem to influence the development of certain variants of squamous epithelium within the urinary tract.

yearjournalcountryeditionlanguage
1987-05-01Journal of Urology
https://doi.org/10.1016/s0022-5347(17)44322-9