6533b831fe1ef96bd1299ae2

RESEARCH PRODUCT

Precision sampling fuels precision oncology: an evolutionary perspective.

José I. LópezEstíbaliz López-fernándezClaudia Manini

subject

Cancer ResearchComputer sciencePerspective (graphical)Sampling (statistics)medicine.diseasecomputer.software_genreBiological EvolutionKidney NeoplasmsClear cell renal cell carcinomaOncologyIntratumor heterogeneityPrecision oncologymedicineHumansData miningPrecision MedicinecomputerCarcinoma Renal Cell

description

Intratumor heterogeneity (ITH) develops in malignant tumors. Precision sampling that captures this tumor variability is essential for the implementation of precision oncology. We highlight the necessity to update current sampling protocols and implement a strategy to ensure ITH detection and characterization. A cost-effective strategy for such sampling has been modeled in clear cell renal cell carcinoma (CCRCC).

yearjournalcountryeditionlanguage
2021-11-01Trends in cancer
10.1016/j.trecan.2021.08.006https://pubmed.ncbi.nlm.nih.gov/34493466