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RESEARCH PRODUCT

Optical Coherence Tomography Angiography of Optic Disc in Eyes With Primary Open-angle Glaucoma and Normal-tension Glaucoma.

Shahzada Najam Ul HassanShahzada Najam Ul HassanAnani P ToshevNorbert PfeifferEsther M. HoffmannAlexander K. Schuster

subject

AdultRetinal Ganglion Cellsmedicine.medical_specialtygenetic structuresOpen angle glaucomaOptic DiskNerve fiber layerOcular hypertensionGlaucoma03 medical and health sciences0302 clinical medicineNerve FibersNormal tension glaucomaOphthalmologymedicineHumansLow Tension GlaucomaFluorescein AngiographyIntraocular PressureAgedRetrospective StudiesAged 80 and overmedicine.diagnostic_testbusiness.industryRetinal VesselsMiddle Agedmedicine.diseaseFluorescein angiographyeye diseasesOphthalmologymedicine.anatomical_structureCross-Sectional Studies030221 ophthalmology & optometryOptic nerveFemaleOcular Hypertensionsense organsVisual Fieldsbusiness030217 neurology & neurosurgeryGlaucoma Open-AngleTomography Optical CoherenceOptic disc

description

PURPOSE To examine vessel density (VD) properties of the optic nerve head in eyes with ocular hypertension (OHT), high-tension glaucoma (HTG), and normal-tension glaucoma (NTG) and to evaluate associations on structural parameters of retinal nerve fiber layer (RNFL). METHODS Three groups of patients with OHT (n=15), HTG (n=36), and NTG (n=22), and a healthy control group (n=23) were included in this study. Peripapillary VD and optic disc flow area were measured using optical coherence tomography angiography, and peripapillary RNFL (pRNFL) thickness was determined. Global and sectoral analysis of optic nerve head vasculature and pRNFL thickness were measured. RESULTS Glaucomatous eyes had lower global peripapillary VD (HTG: 54.04±5.11, NTG: 54.74±6.37) compared with nonglaucomatous eyes (OHT: 59.72±1.63, controls: 61.35±2.47). VD parameters of the optic disc were comparable between the control and OHT group and between the HTG and NTG group. In the HTG and NTG groups we found significant correlations between average peripapillary VD and global pRNFL thickness (HTG ρ=0.71, P<0.001; NTG ρ=0.65, P=0.001). This was true for all sectors except for the temporal position. CONCLUSIONS Overall, glaucomatous eyes had lower peripapillary VD compared with normal and OHT eyes. There is a strong relationship between the peripapillary structure of RNFL and its vasculature.

yearjournalcountryeditionlanguage
2019-03-01Journal of glaucoma
10.1097/ijg.0000000000001184https://pubmed.ncbi.nlm.nih.gov/30624391