6533b832fe1ef96bd129a29b

RESEARCH PRODUCT

Synthesis, mechanical and thermal rheological properties of new gellan gum derivatives

Giovanna PitarresiJoão F. ManoGaetano GiammonaStefano AgnelloFabio Salvatore PalumboRui L. ReisLuca Gasperini

subject

Thermal scanning rheologyCarbonateCarbonatesPhysical hydrogelsMechanical properties02 engineering and technology010402 general chemistryPolysaccharide01 natural sciencesBiochemistryGellan gumNitrophenolschemistry.chemical_compoundRheologyPhysical hydrogelStructural BiologyAmidePolymer chemistryThermalAminesMolecular BiologyAlkylAminechemistry.chemical_classificationScience & TechnologyNitrophenolTissue EngineeringChemistryPolysaccharides BacterialTemperatureOctadecylamineHydrogelsGeneral Medicine021001 nanoscience & nanotechnologyGellan gum0104 chemical sciences3. Good healthHydrogelCovalent bondSelf-healing hydrogels0210 nano-technologyRheologyMechanical propertie

description

New derivatives of gellan gum (GG) were prepared by covalent attachment of octadecylamine (C18- NH2) to polysaccharide backbone via amide linkage by using bis(4-nitrophenyl) carbonate (4-NPBC) as a coupling agent. The effect of the alkyl chain grafted onto hydrophilic backbone of high molecular weight GG was investigated in terms of physicochemical properties and ability of new derivatives to form hydrogels. A series of hydrogels was obtained in solutions with different kind and concentration of ions and their stability and mechanical properties were evaluated. The obtained derivatives resulted soluble at temperature lower than starting GG and physicochemical properties of obtained hydrogels suggested their potential use in biomedical field.

yearjournalcountryeditionlanguage
2017-02-01
10.1016/j.ijbiomac.2017.02.029https://dx.doi.org/10.1016/j.ijbiomac.2017.02.029