6533b832fe1ef96bd129a2f1

RESEARCH PRODUCT

Subtle genotypic changes can be observed soon after diagnosis in Mycobacterium tuberculosis infection.

Emilio BouzaMaría Jesús Ruiz-serranoMarta HerranzLaura Pérez-lagoDarío García-de-viedmaIñaki ComasAna Isabel Rodríguez Borlado

subject

0301 basic medicineMicrobiology (medical)Functional roleAdultMaleTuberculosisGenotyping Techniques030106 microbiologyAdaptation BiologicalSingle-nucleotide polymorphismBiologyMicrobiologyPolymorphism Single NucleotideMycobacterium tuberculosisEvolution Molecular03 medical and health sciencesGenotypemedicineHumansTuberculosisAgedAged 80 and overTransmission (medicine)MicroevolutionGenetic VariationGeneral MedicineMycobacterium tuberculosisMiddle Agedbacterial infections and mycosesmedicine.diseasebiology.organism_classificationVirologyInfectious DiseasesFemale

description

Clonal variants of Mycobacterium tuberculosis (MTB) coexist in specific patients, although the dynamics of their emergence is unknown. We used MIRU-VNTR to detect microevolution leading to variants of MTB in 3 out of 19 patients (15%) soon after diagnosis (61-85 days). Most harbored SNPs and for some of them a potential functional role was suggested. Microevolution in tuberculosis seems to occur sooner and more often than expected and could affect tracking of transmission.

yearjournalcountryeditionlanguage
2016-02-18International journal of medical microbiology : IJMM
10.1016/j.ijmm.2016.05.007https://pubmed.ncbi.nlm.nih.gov/27247102