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RESEARCH PRODUCT
Dermal dendritic cells, but not Langerhans cells, are critical in murine single epicutaneous sensitization
Li-fang WangHsien-ching ChiuBjörn E. ClausenChing Yi LiuJi Chen HoChih Hung LeeYng Cun TaJau-shiuh ChenChien Hui Hongsubject
Dermal Dendritic CellsTh2 responseDermatologyBiochemistryDermatitis AtopicAtopyMiceTh2 CellsAntigens CDCell MovementmedicineAnimalsHumansEpicutaneous sensitizationMolecular BiologyCells CulturedSkinMice Inbred BALB Cbusiness.industryDendritic CellsAtopic dermatitisAllergensTh1 Cellsmedicine.diseaseMice Inbred C57BLLangerhans CellsImmunologyCytokinesTh1 responsebusinessIntegrin alpha Chainsdescription
A murine repeated protein-patch model has been established to study epicutaneous sensitization in atopic dermatitis. This model has shown a predominant Th2 and a weak Th1 response in both BALB/c and C57BL/6 mice. However, Th responses induced in the repeated model are not consistent with the generally accepted theory that BALB/c and C57BL/6 mice are Th2 and Th1 prone and are representatives of human atopy and non-atopy, respectively. In this study, a single protein-patch model was established, which showed in addition to the Th2 response, a remarkable Th1 response in C57BL/6 mice, but not in BALB/c mice. Moreover, using muLangerin-DTR mice, we demonstrated that dermal dendritic cells, but not Langerhans cells, are critical in single epicutaneous sensitization in both strains of mice.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2014-10-28 | Experimental Dermatology |