6533b832fe1ef96bd129a44b

RESEARCH PRODUCT

Pattern of in-hospital changes in drug use in the older people from 2010 to 2016

Franchi CarlottaArdoino IlariaNobili AlessandroPasina Luca Pier Mannuccio MannucciMarengoni AlessandraPerticone FrancescoTettamanti MauroSalerno FrancescoCorrao SalvatoreLicata GiuseppeVioli Francesco Gino Roberto CorazzaMaura Marcucci Tarek Kamal Eldin Maria Pia Donatella Di BlancaLanzo GiovannaAstuto SarahCortesi LauraDomenico PriscoSilvestri ElenaCenci CaterinaEmmi GiacomoBiolo GianniGuarnieri GianfrancoZanetti MichelaFernandes GiovanniChiuch MassimilianoVanoli MassimoGrignani GiuliaCasella Gianluca Edoardo Alessandro PulixiBernardi Mauro Silvia Li BassiSanti LucaZaccherini GiacomoElmo MannarinoGraziana LupattelliVanessa BianconiFrancesco PaciulloNuti RanuccioValenti RobertoRuvio MartinaCappelli SilviaPalazzuoli AlbertoSalvatore Teresa Ferdinando Carlo SassoGirelli DomenicoOlivieri OlivieroMatteazzi ThomasBarbagallo MarioPlances LidiaAlcamo RobertaCalvo LuigiValenti MariaZoli MarcoArnò Raffaella Franco Laghi Pasini Pier Leopoldo CapecchiBicchi MaurizioPalasciano Giuseppe Maria Ester ModeoPeragine MariaPappagallo FabrizioPugliese Stefania Carla Di GennaroPostiglione Alfredo Maria Rosaria Barbella Francesco De StefanoMaria Domenica CappelliniFabio GiovannaSeghezzi Sonia Margherita Migone De AmicisMancarella MartaMari Daniela Paolo Dionigi RossiDamanti Sarah Barbara Brignolo OttoliniBonini GiuliaMiceli Emanuela Marco Vincenzo LentiPadula DonatellaMurialdo GiovanniMarra AlessioCattaneo Federico Maria Beatrice SecchiGhelfi DavideAnastasio LuigiSofia LuciaLuigi Maria CarboneDavì Giovanni Maria Teresa GuagnanoSestili SimonaMancuso GerardoCalipari DanielaBartone Mosè Maria Rachele Meroni Paolo Cavallo PerinLorenzati BartolomeoGruden GabriellaBruno GraziellaAmione CristinaFornengo PaoloTassara RodolfoMelis DeborahRebella LaraDelitala GiuseppePretti Vincenzo Maristella Salvatora MasalaPes ChiaraBolondi LuigiRasciti LeonardoSerio Ilaria Filippo Rossi FanelliAmoroso AntonioMolfino AlessioPetrillo EnricoZuccalà GiuseppeFranceschi Francesco Guido De MarcoChiara CordischiMarta SabbatiniD’aurizio GabriellaRomanelli GiuseppeAmolini ClaudiaChiesa DeborahPicardi Antonio Umberto Vespasiani GentilucciGallo PaoloAnnoni GiorgioCorsi MaurizioZazzetta SaraBellelli GiuseppeSzabo HajnalkaArturi FrancoSuccurro ElenaRubino MariangelaSesti GiorgioLoria Paola Maria Angela BecchiMartucci GianfrancoFantuzzi AlessandraMaurantonio Mauro Maria Grazia Serra Maria Antonietta BleveGasbarrone Laura Maria Rosaria SajevaBrucato AntonioGhidoni Silvia Paola Di CoratoGiancarlo AgnelliEmanuela MarchesiniFabris FabrizioCarlon MichelaTuratto FrancescaBaritusso AldoTuratto FrancescaAmabile AnnalisaOmenetto ElisabettaScarinzi PaoloManfredini RobertoMolino ChristianPala MarcoFabbian FabioBoari Benedetta Alfredo De GiorgiPaolisso Giuseppe Maria Rosaria Rizzo Maria Teresa LaietaRini GiovanbattistaMansueto PasqualePepe IleniaBorghi ClaudioStrocchi Enrico Valeria De SandoPareo IlariaSabbà Carlo Francesco Saverio VellaSuppressa PatriziaValerio RaffaellaAgosti PasqualeFontana FlaviaLoparco FrancescaPugliese StefaniaCapobianco CaterinaFenoglio LuigiBracco Christian Alessia Valentina GiraudoTesta ElisaSerraino CristinaFargion SilviaBonara PaolaPeriti GiuliaPorzio MariannaTiraboschi SliviaPeyvandi FloraTedeschi AlbertoRossio RaffaellaMonzani ValterSavojardo ValeriaFolli ChristianMagnini MariaConca AlessioGobbo GiuliaConca AlessioPallini GiadaValenti MiriamCarlo L. BalduiniBertolino GiampieraProvini StellaQuaglia FedericaDallegri FrancoOttonello LucianoLiberale Luca Wu Sheng ChinCarassale LauraCaporotundo SilviaTraisci Giancarlo Lucrezia De Feudis Silvia Di Carlo Nicola Lucio LiberatoBuratti AlbertoTognin Tiziana Giovanni Battista BianchiGiaquinto SabrinaPurrello Francesco Antonino Di PinoPiro SalvatoreRozzini RenzoFalanga LinaSpazzini ElenaMontrucchio GiuseppeGreco ElisabettaTizzani PietroPetitti PaoloPerciccante AntonioCoralli AlessiaSalmi RaffaellaGaudenzi PiergiorgioGamberini SusannaSemplicini AndreaGottardo LuciaVendemiale GianluigiServiddio GaetanoForlano RobertaMasala CesareMammarella AntonioRaparelli ValeriaBasili StefaniaPerri LudovicaLandolfi RaffaeleMontalto MassimoMirijello AntonioVallone CarlaBellusci MartinoSetti DonatellaPedrazzoli FilippoGuasti LuiginaCastiglioni LuanaMaresca AndreaSquizzato AlessandroMolaro MartaMarco BertolottiMussi Chiara Maria Vittoria LibbraAndrea Di MiceliElisa PellegriniCarulli LuciaVeltri FrancescaSciacqua AngelaQuero MicheleBagnato ChiaraColangelo LidiaFalbo Tania Roberto De GiorgioMauro Dalla SerraGrasso ValentinaRuggeri EugenioIlaria BenzoniSalvi AndreaRoberto LeonardiGrassini ChiaraMascherona IleniaGiorgio MinelliMaltese FrancescaDamiani GiampaoloCapeci WilliamMassimo Mattioli Giuseppe Pio MartinoLorenzo BiondiOrmas MonicaPettinari PietroRomiti RobertoMessina SilviaCavallaro FedericaGhio RiccardiFavorini Serena Anna Dal ColMinisola SalvatoreColangelo LucianoAfeltra AntonellaAlemanno PamelaMarigliano Benedetta Maria Elena PipitaCastellino PietroBlanco JulienZanoli LucaMarco Natale CattaneoFracasso PaolaMaria Valentina AmorusoSaracco ValterFogliati MarisaBussolino CarloDurante VittorioEusebi GiovannaTirotta DanielaMete FrancescaGino MiriamCittadini AntonioVigorito CarloArcopinto MicheleSalzano AndreaBobbio Emanuele Alberto Maria MarraSirico DomenicoMoreo GuidoScopelliti FrancescoGasparini FrancescaCocca MelissaBallestrero AlbertoFerrando FabioBerra SergioDassi Simonetta Maria Cristina NavaGraziella BrunoGhidoni SilviaAmione CristinaBaldassarre StefanoFragapani SalvatoreGruden GabriellaGalanti GiorgioMascherini GabrielePetri CristianStefani LauraGirino MargheritaPiccinelli ValeriaNasso FrancescoGioffrè VincenzaPasquale MariaScattolin GiuseppeMartinelli SergioTurrin MauroSechi LeonardoCatena CristinaColussi Gianluca Ramirez Duque Nieves Muela Molinero Alberto Abad Requejo Pedro Lopez Pelaez VanessaLara Tamargo Corbella Viros XavierFrancesc Formiga Diez Manglano Jesus Bejarano Tello Esperanza Del Corral Behamonte Esther Sevil Puras MariaRomero Manuel Pinilla Llorente Blanca Lopez Gonzalez-cobos CristinaVillalba Garcia M. VictoriaSaez LopezBosco Juan Sanz Baena Susana Arroyo Gallego Marta Gonzalez Becerra Concepcion Fernandez Moyano Antonio Mercedes Gomez Hernandez Manuel Poyato Borrego Pacheco Cuadros Raquel Perez Rojas Florencia Garcia Olid Beatriz Carrascosa Garcia Sara Gonzalez-cruz Cervellera Alfonso Peinado Martinez Marta Sara Carrascosa Garcia Ruiz Cantero Alberto Albarracín Arraigosa Antonio Godoy Guerrero Montserrat Barón Ramos Miguel ÁNgel Machin Jose Manuel Novo Veleiro Ignacio Alvela Suarez LucíaAlfonso Lopez Rubal Bran David Iñiguez Vazquez Iria Rios Prego Monica

subject

RegistrieMalepharmacoepidemiologyEpidemiologyDischarged alive030204 cardiovascular system & hematologyinternal medicine and geriatric warddrug use; excessive polypharmacy; internal medicine and geriatric wards; older people; pharmacoepidemiology; polypharmacyexcessive polypharmacyolder people0302 clinical medicineDrug PrescriptionRisk Factors80 and overPharmacology (medical)030212 general & internal medicineRegistriesAt-Risk Populationmedia_commonAged 80 and overOvertimedrug use excessive polypharmacy internal medicine and geriatric wards older people pharmacoepidemiology polypharmacyinternal medicine and geriatric wardsPharmacoepidemiologyHospitalizationItalyFemaleMedical emergencyHumanDrugmedicine.medical_specialtymedia_common.quotation_subjectSocio-culturaleDrug Prescriptions03 medical and health sciencesHospital dischargemedicineInternal MedicineHumanspolypharmacyAgeddrug usePolypharmacyInpatientsbusiness.industryRisk Factormedicine.diseasedrug use; excessive polypharmacy; internal medicine and geriatric wards; older people; pharmacoepidemiology; polypharmacy; Aged; Aged 80 and over; Drug Prescriptions; Female; Hospitalization; Humans; Internal Medicine; Italy; Male; Polypharmacy; Registries; Risk Factors; InpatientsEmergency medicinePolypharmacyOlder peoplebusiness

description

Purpose: To assess the pattern of in-hospital changes in drug use in older patients from 2010 to 2016. Methods: People aged 65 years or more acutely hospitalized in those internal medicine and geriatric wards that did continuously participate to the REgistro POliterapie Società Italiana di Medicina Interna register from 2010 to 2016 were selected. Drugs use were categorized as 0 to 1 drug (very low drug use), 2 to 4 drugs (low drug use), 5 to 9 drugs (polypharmacy), and 10 or more drugs (excessive polypharmacy). To assess whether or not prevalence of patients in relation to drug use distribution changed overtime, adjusted prevalence ratios (PRs) was estimated with log-binomial regression models. Results: Among 2120 patients recruited in 27 wards continuously participating to data collection, 1882 were discharged alive and included in this analysis. The proportion of patients with very low drug use (0-1 drug) at hospital discharge increased overtime, from 2.7% in 2010 to 9.2% in 2016. Results from a log-logistic adjusted model confirmed the increasing PR of these very low drug users overtime (particularly in 2014 vs 2012, PR 1.83 95% CI 1.14-2.95). Moreover, from 2010 to 2016, there was an increasing number of patients who, on polypharmacy at hospital admission, abandoned it at hospital discharge, switching to the very low drug use group. Conclusion: This study shows that in internal medicine and geriatric wards continuously participating to the REgistro POliterapie Società Italiana di Medicina Interna register, the proportion of patients with a very low drug use at hospital discharge increased overtime, thus reducing the therapeutic burden in this at risk population.

yearjournalcountryeditionlanguage
2017-01-01
10.1002/pds.4330http://hdl.handle.net/11392/2381188