0000000000787037

AUTHOR

Raparelli Valeria

showing 7 related works from this author

Frequency of Left Ventricular Hypertrophy in Non-Valvular Atrial Fibrillation

2015

Left ventricular hypertrophy (LVH) is significantly related to adverse clinical outcomes in patients at high risk of cardiovascular events. In patients with atrial fibrillation (AF), data on LVH, that is, prevalence and determinants, are inconsistent mainly because of different definitions and heterogeneity of study populations. We determined echocardiographic-based LVH prevalence and clinical factors independently associated with its development in a prospective cohort of patients with non-valvular (NV) AF. From the "Atrial Fibrillation Registry for Ankle-brachial Index Prevalence Assessment: Collaborative Italian Study" (ARAPACIS) population, 1,184 patients with NVAF (mean age 72 ± 11 yea…

RegistrieMaleCross-sectional studyMyocardial InfarctionLongitudinal StudieLeft ventricular hypertrophyCohort Studiesnon-valvular atrial fibrillationAtrial Fibrillation80 and overPrevalenceechocardiographyMyocardial infarctionLongitudinal StudiesProspective StudiesRegistriesProspective cohort studyUltrasonographyAged 80 and overeducation.field_of_studyMedicine (all)Atrial fibrillationDiabetes MellituMiddle AgedLeft Ventricularleft ventricular hypertrophyItalyHypertensionCardiologyAge Distribution; Aged; Aged 80 and over; Ankle Brachial Index; Atrial Fibrillation; Cohort Studies; Cross-Sectional Studies; Diabetes Mellitus; Female; Humans; Hypertension; Hypertrophy Left Ventricular; Italy; Logistic Models; Longitudinal Studies; Male; Middle Aged; Myocardial Infarction; Peripheral Arterial Disease; Prevalence; Prospective Studies; Ultrasonography; Registries; Cardiology and Cardiovascular Medicine; Medicine (all)Hypertrophy Left VentricularFemaleCardiology and Cardiovascular MedicineHumanmedicine.medical_specialtyLogistic ModelPopulationConcentric hypertrophySocio-culturalenon-valvular atrial fibrillation left ventricular hypertrophy echocardiography cardiovascular diseasesPeripheral Arterial DiseaseAge DistributionInternal medicinemedicineDiabetes MellitusHumansAnkle Brachial Indexcardiovascular diseaseseducationAgedCross-Sectional Studiebusiness.industryAge Distribution; Aged; Aged 80 and over; Ankle Brachial Index; Atrial Fibrillation; Cohort Studies; Cross-Sectional Studies; Diabetes Mellitus; Female; Humans; Hypertension; Hypertrophy Left Ventricular; Italy; Logistic Models; Longitudinal Studies; Male; Middle Aged; Myocardial Infarction; Peripheral Arterial Disease; Prevalence; Prospective Studies; Ultrasonography; Registries; Cardiology and Cardiovascular MedicineOdds ratioHypertrophymedicine.diseasecardiovascular diseasesProspective StudieCross-Sectional StudiesLogistic ModelsCohort StudiebusinessAge Distribution; Aged; Aged 80 and over; Ankle Brachial Index; Atrial Fibrillation; Cohort Studies; Cross-Sectional Studies; Diabetes Mellitus; Female; Humans; Hypertension; Hypertrophy Left Ventricular; Italy; Logistic Models; Longitudinal Studies; Male; Middle Aged; Myocardial Infarction; Peripheral Arterial Disease; Prevalence; Prospective Studies; Ultrasonography; Registries
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Pattern of in-hospital changes in drug use in the older people from 2010 to 2016

2017

Purpose: To assess the pattern of in-hospital changes in drug use in older patients from 2010 to 2016. Methods: People aged 65 years or more acutely hospitalized in those internal medicine and geriatric wards that did continuously participate to the REgistro POliterapie Società Italiana di Medicina Interna register from 2010 to 2016 were selected. Drugs use were categorized as 0 to 1 drug (very low drug use), 2 to 4 drugs (low drug use), 5 to 9 drugs (polypharmacy), and 10 or more drugs (excessive polypharmacy). To assess whether or not prevalence of patients in relation to drug use distribution changed overtime, adjusted prevalence ratios (PRs) was estimated with log-binomial regression mo…

RegistrieMalepharmacoepidemiologyEpidemiologyDischarged alive030204 cardiovascular system & hematologyinternal medicine and geriatric warddrug use; excessive polypharmacy; internal medicine and geriatric wards; older people; pharmacoepidemiology; polypharmacyexcessive polypharmacyolder people0302 clinical medicineDrug PrescriptionRisk Factors80 and overPharmacology (medical)030212 general & internal medicineRegistriesAt-Risk Populationmedia_commonAged 80 and overOvertimedrug use excessive polypharmacy internal medicine and geriatric wards older people pharmacoepidemiology polypharmacyinternal medicine and geriatric wardsPharmacoepidemiologyHospitalizationItalyFemaleMedical emergencyHumanDrugmedicine.medical_specialtymedia_common.quotation_subjectSocio-culturaleDrug Prescriptions03 medical and health sciencesHospital dischargemedicineInternal MedicineHumanspolypharmacyAgeddrug usePolypharmacyInpatientsbusiness.industryRisk Factormedicine.diseasedrug use; excessive polypharmacy; internal medicine and geriatric wards; older people; pharmacoepidemiology; polypharmacy; Aged; Aged 80 and over; Drug Prescriptions; Female; Hospitalization; Humans; Internal Medicine; Italy; Male; Polypharmacy; Registries; Risk Factors; InpatientsEmergency medicinePolypharmacyOlder peoplebusiness
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Clinical Severity, Age, and Sex Overcome Cardiometabolic Morbidities but Not Stroke as Predictors of Mortality in Elderly Inpatients: Data From the R…

2016

MalePediatricsmedicine.medical_specialtyREPOSI studyClinical severity age stroke risk factors elderly REPOSI studySocio-culturale030204 cardiovascular system & hematologyAge and sexelderlySeverity of Illness Index03 medical and health sciencesSex Factors0302 clinical medicineMetabolic Diseasesmedicinerisk factorsHumansClinical severityClinical severityHospital MortalityRegistries030212 general & internal medicineStrokeAgedAged 80 and overInpatientsbusiness.industryAge Factorsmedicine.diseaseStrokeageItalyCardiovascular DiseasesFemaleMorbidityGeriatrics and GerontologybusinessJournal of the American Geriatrics Society
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Hemostatic balance in patients with liver cirrhosis: Report of a consensus conference.

2016

Abstract Patients with cirrhosis present with hemostatic alterations secondary to reduced availability of pro-coagulant and anti-coagulant factors. The net effect of these changes is a rebalanced hemostatic system. The Italian Association of the Study of the Liver (AISF) and the Italian Society of Internal Medicine (SIMI) promoted a consensus conference on the hemostatic balance in patients with cirrhosis. The consensus process started with the review of the literature by a scientific board of experts and ended with a formal consensus meeting in Rome in December 2014. The statements were graded according to quality of evidence and strength of recommendations, and approved by an independent …

Liver CirrhosisCirrhosisBleeding; Cirrhosis; Hemostasis; Thrombosis; Hepatology; GastroenterologySettore MED/09 - Medicina InternaBleeding; Cirrhosis; Hemostasis; Thrombosis; Anticoagulants; Coagulants; Drug Monitoring; Esophageal and Gastric Varices; Gastrointestinal Hemorrhage; Humans; Liver Cirrhosis; Postoperative Hemorrhage; Thrombosis; Blood Coagulation Tests; Hemostasis; Hepatology; Gastroenterology0302 clinical medicineEsophageal and Gastric VariceBlood coagulation testConsensus conferenceGastroenterologyThrombosisOptimal managementCirrhosisCoagulant030220 oncology & carcinogenesisThrombosi030211 gastroenterology & hepatologyBlood Coagulation TestsDrug MonitoringGastrointestinal HemorrhageHumanmedicine.medical_specialtyLiver CirrhosiBleeding; Cirrhosis; Hemostasis; Thrombosis; Gastroenterology; HepatologyPostoperative HemorrhageEsophageal and Gastric VaricesNO03 medical and health sciencesInternal medicinemedicineHumansIn patientIntensive care medicineHemostasisCirrhosiHepatologybusiness.industryCoagulantsBleeding; Cirrhosis; Hemostasis; ThrombosisBleedingAnticoagulantAnticoagulantsThrombosisHepatologyHemostasiBlood Coagulation Testmedicine.diseaseSurgeryHemostasisbusinessDigestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
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Adherence to antithrombotic therapy guidelines improves mortality among elderly patients with atrial fibrillation: insights from the REPOSI study

2016

Background: Atrial fibrillation (AF) is associated with a substantial risk of thromboembolism and mortality, significantly reduced by oral anticoagulation. Adherence to guidelines may lower the risks for both all cause and cardiovascular (CV) deaths. Methods: Our objective was to evaluate if antithrombotic prophylaxis according to the 2012 European Society of Cardiology (ESC) guidelines is associated to a lower rate of adverse outcomes. Data were obtained from REPOSI; a prospective observational study enrolling inpatients aged ≥65 years. Patients enrolled in 2012 and 2014 discharged with an AF diagnosis were analysed. Results: Among 2535 patients, 558 (22.0 %) were discharged with a diagnos…

Antithrombotic therapy; Atrial fibrillation; Elderly; Guidelines; Outcomes; Cardiology and Cardiovascular MedicineMaleRegistrieTime Factorsantithrombotic therapy; atrial fibrillation; elderly; guidelines; outcomesAtrial fibrillation (AF)Practice PatternsKaplan-Meier Estimate030204 cardiovascular system & hematologyGuidelineoutcomesCoronary artery disease0302 clinical medicineElderlyRisk FactorsAtrial FibrillationAntithrombotic80 and overAge Factor030212 general & internal medicineRegistriesguidelinesAntithrombotic therapy Atrial fibrillation Elderly Guidelines OutcomesPractice Patterns Physicians'OutcomeAged 80 and overFibrinolytic AgentAge FactorsAtrial fibrillationGeneral MedicineTreatment OutcomeItalyAtrial fibrillation (AF) thromboembolism antithrombotic prophylaxisPractice Guidelines as TopicCardiologyFemaleGuideline AdherenceCardiology and Cardiovascular MedicineHumanAntithrombotic therapy; Atrial fibrillation; Elderly; Guidelines; Outcomes; Age Factors; Aged; Aged 80 and over; Atrial Fibrillation; Chi-Square Distribution; Female; Fibrinolytic Agents; Guideline Adherence; Humans; Italy; Kaplan-Meier Estimate; Logistic Models; Male; Practice Patterns Physicians'; Proportional Hazards Models; Registries; Risk Assessment; Risk Factors; Thromboembolism; Time Factors; Treatment Outcome; Practice Guidelines as Topic; Cardiology and Cardiovascular Medicinemedicine.medical_specialtyLogistic ModelTime FactorSocio-culturaleLower riskRisk Assessment03 medical and health sciencesFibrinolytic AgentsInternal medicineThromboembolismmedicineHumansProportional Hazards ModelsAgedAntithrombotic therapyPhysicians'Chi-Square Distributionbusiness.industryProportional hazards modelRisk FactorSettore MED/09 - MEDICINA INTERNAGuidelinethromboembolismmedicine.diseaseAtrial fibrillationLogistic ModelsProportional Hazards Modelantithrombotic prophylaxisbusinessChi-squared distributionFibrinolytic agent
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The SIMI Gender '5 Ws' Rule for the integration of sex and gender-related variables in clinical studies towards internal medicine equitable research

2022

AbstractBiological sex and sociocultural gender matter when it comes to health and diseases. They have been both proposed as the undeniable gateways towards a personalized approach in care delivery. The Gender Working Group of the Italian Society of Internal Medicine (SIMI) was funded in 2019 with the aim of promoting good practice in the integration of sex and gender domains in clinical studies. Starting from a narrative literature review and based on regular meetings which led to a shared virtual discussion during the national SIMI congress in 2021, the members of the WG provided a core operational framework to be applied by internal medicine (IM) specialists to understand and implement t…

MaleSettore MED/09 - Medicina InternaClinical studies; Data collection; Gender; Internal medicine; SexSocial SupportGender IdentityGenderClinical studieClinical studies; Data collection; Gender; Internal medicine; Sex; Delivery of Health Care; Female; Humans; Italy; Male; Social Support; Gender Identity; Internal MedicineItalyEmergency MedicineData collectionHumansFemaleSexDelivery of Health CareInternal medicineClinical studies
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Implementation of the Frailty Index in hospitalized older patients: Results from the REPOSI register

2018

Abstract Background Frailty is a state of increased vulnerability to stressors, associated to poor health outcomes. The aim of this study was to design and introduce a Frailty Index (FI; according to the age-related accumulation of deficit model) in a large cohort of hospitalized older persons, in order to benefit from its capacity to comprehensively weight the risk profile of the individual. Methods Patients aged 65 and older enrolled in the REPOSI register from 2010 to 2016 were considered in the present analyses. Variables recorded at the hospital admission (including socio-demographic, physical, cognitive, functional and clinical factors) were used to compute the FI. The prognostic impa…

GerontologyMaleMultivariate analysisFrailty; Internal medicine and geriatric wards; Multimorbidity; Physical and cognitive impairment; Internal MedicinePhysical and cognitive impairmentPsychological interventionPredictive Value of TestSeverity of Illness Index0302 clinical medicineInternal medicine and geriatric wardsInterquartile rangeFrailty Internal medicine and geriatric wards Multimorbidity Physical and cognitive impairment80 and overMedicine030212 general & internal medicineProspective StudiesHospital MortalityProspective cohort studyMultivariate AnalysiAged 80 and overFrailtyPrognosisFrailty; Internal medicine and geriatric wards; Multimorbidity; Physical and cognitive impairment; Aged; Aged 80 and over; Female; Frailty; Geriatric Assessment; Hospitalization; Humans; Italy; Male; Multimorbidity; Multivariate Analysis; Predictive Value of Tests; Prognosis; Prospective Studies; Regression Analysis; Survival Analysis; Frail Elderly; Hospital Mortality; Severity of Illness IndexHospitalizationItalyPredictive value of testsRegression AnalysisFemaleSurvival AnalysiCohort studyHumanPrognosiFrail ElderlyFrailty; Internal medicine and geriatric wards; Multimorbidity; Physical and cognitive impairment; Aged; Aged 80 and over; Female; Frailty; Geriatric Assessment; Hospitalization; Humans; Italy; Male; Multimorbidity; Multivariate Analysis; Predictive Value of Tests; Prognosis; Prospective Studies; Regression Analysis; Survival Analysis; Frail Elderly; Hospital Mortality; Severity of Illness Index; Internal MedicineSocio-culturaleRegression Analysi03 medical and health sciencesPredictive Value of TestsSeverity of illnessInternal MedicineHumansGeriatric AssessmentSurvival analysisAgedbusiness.industryMultimorbiditySurvival AnalysisInternal medicine and geriatric wardProspective StudieMultivariate Analysisbusiness030217 neurology & neurosurgery
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