6533b832fe1ef96bd129ae50
RESEARCH PRODUCT
Association of renal resistive index with aortic pulse wave velocity in hypertensive patients
Giuseppe MulèAnna Carola ForaciFrancesco D'ignotoCalogero GeraciGiulio GeraciMassimiliano MorrealeSantina CottoneM. Mogaverosubject
AdultMalemedicine.medical_specialtySettore MED/09 - Medicina InternaEpidemiologyPopulationRenal functionPulse Wave AnalysisKidneyRenal CirculationVascular StiffnessPredictive Value of TestsRisk Factorsmedicine.arteryInternal medicineHumansMedicineRenal Insufficiency ChronicUltrasonography Doppler ColoreducationPulse wave velocityAortaAgedAortic pulse wave velocity arterial hypertension arterial stiffness renal Doppler ultrasonography renal resistive indexSettore MED/14 - Nefrologiaeducation.field_of_studyKidneyAortabusiness.industryMiddle Agedmedicine.diseaseSettore MED/11 - Malattie Dell'Apparato CardiovascolareCross-Sectional Studiesmedicine.anatomical_structureHypertensionArterial stiffnessCardiologyFemaleVascular ResistanceAortic stiffnessCardiology and Cardiovascular MedicinebusinessKidney diseasedescription
Background: Recent data suggest that renal haemodynamic parameters obtained by duplex Doppler sonography, especially the intrarenal resistive index (RI), may be associated with systemic vascular changes. However, conflicting data exist about the independent relationship between aortic stiffness and RI. The aim of this study was to evaluate the relationship between RI and arterial stiffness, assessed by aortic pulse wave velocity (aPWV), in hypertensive patients. Design: Cross-sectional study. Methods: We enrolled 264 hypertensive subjects aged between 30 and 70 years. They were divided into two groups, either with normal renal function (n=140) or with chronic kidney disease (CKD) (n=124). Each patient underwent assessment of ultrasonographic renal RI and measurement of aPWV through oscillometric device. Results: Patients with renal RI>0.7 showed higher values of aPWV, both in the overall population (p<0.001) and in the subgroups with (p<0.01) and without CKD (p<0.01). Moreover, statistically significant correlations were observed between aPWV and RI in the whole population (r=0.38, p<0.001) and in the subgroups with (r=0.35, p<0.001) and without CKD (r=0.31, p<0.001). These correlations held even after adjustment for several confounding factors in multivariate analyses. Conclusions: Our results seem to corroborate the concept that the RI may be considered as a marker of systemic vascular changes and therefore a predictor of cardiovascular risk.
year | journal | country | edition | language |
---|---|---|---|---|
2014-02-13 |