6533b833fe1ef96bd129b692

RESEARCH PRODUCT

Novel bis(tetrahydropyrrolo[3,4-b]carbazoles) linked with aliphatic chains: synthesis and structural aspects

Ulf PindurKerstin U. Meyer

subject

chemistry.chemical_compoundStereochemistryChemistryMoleculeCombinatorial chemistryCycloadditionDNA

description

Syntheses of novel bis(tetrahydropyrrolo[3,4-b]carbazoles) by a [4+2]cycloaddition reaction are described. By variation of dienophiles bis(tetrahydropyrrolo[3,4-b]carbazoles) of varying aliphatic spacer length could be obtained in high yields. These conformationally highly flexible molecules represent an interesting class of compounds, believed to have an affinity towards DNA, as potential DNA ligands.

https://doi.org/10.1039/b009731o