6533b833fe1ef96bd129b72f

RESEARCH PRODUCT

Effect of ischaemic preconditioning, cardiopulmonary bypass and myocardial ischaemic/reperfusion on free radical generation in CABG patients.

Jari LaurikkaMikko VuolleMatti TarkkaZhongkai WuErkki PehkonenSeppo KaukinenLiisa KaukinenEva L. HonkonenJussi Eloranta

subject

Malemedicine.medical_specialtyFree RadicalsIschemiaCardiac indexMyocardial IschemiaHemodynamicsVentricular Function Leftlaw.inventionRight ventricular ejection fractionPostoperative ComplicationslawInternal medicineCardiopulmonary bypassmedicineHumansRadiology Nuclear Medicine and imagingCardiac OutputCoronary Artery BypassCoronary sinusAgedMyocardial StunningCardiopulmonary Bypassbusiness.industryStunningHemodynamicsStroke VolumeMiddle Agedmedicine.diseaseAnesthesiaIschemic Preconditioning MyocardialCardiologyIschemic preconditioningSurgeryFemaleCardiology and Cardiovascular Medicinebusiness

description

Abstract Objective: To investigate the free radicals (FR) generation after ischaemic preconditioning and cardiopulmonary bypass and during reperfusion in CABG patients, and the role of ischaemic preconditioning. Methods: Forty-three CABG patients were randomised into an ischaemic preconditioning and a control group. The protocol for ischaemic preconditioning was two cycles of 2-min ischaemia followed by 3-min reperfusion. Free radicals were measured using electron spin resonance spectroscopy. Global and right heart functions were collected. Results: The free radicals generation in coronary sinus blood in the ischaemic preconditioning group was 9.7 and 16.6% after the ischaemic preconditioning protocol and 10 min after declamping, 6.8 and 13.3% in the controls. The free radicals in arterial samples were, respectively, 21, 14, 10 and 9% at 10 min, 1, 2 and 24 h after reperfusion. Cardiac index (CI) and right ventricular ejection fraction (RVEF) were improved by ischaemic preconditioning. Conclusion: Both ischaemic preconditioning and cardiopulmonary bypass induced free radicals generation. Although ischaemic preconditioning had no effect on free radicals generation after the operation, it protected against postoperative stunning.

yearjournalcountryeditionlanguage
2001-06-23Cardiovascular surgery (London, England)
10.1016/s0967-2109(00)00146-0https://pubmed.ncbi.nlm.nih.gov/11420161