6533b833fe1ef96bd129c2c0

RESEARCH PRODUCT

Factors influencing survival after resection of pancreatic cancer. A DNA analysis and a histomorphologic study

S. StörkelMichael StöckleTheo JungingerStefan WellekThomas C. Böttger

subject

MaleCancer Researchmedicine.medical_specialtyPathologyPancreatic diseaseMultivariate analysisGastroenterologyPolyploidyPancreatectomyText miningPancreatic cancerInternal medicinemedicineHumansStomach cancerLymph nodeNeoplasm StagingCell NucleusUnivariate analysisbusiness.industryDNA NeoplasmPrognosismedicine.diseaseDiploidyPancreatic NeoplasmsSurvival Ratemedicine.anatomical_structureOncologyLymphatic MetastasisMultivariate AnalysisLymph Node ExcisionFemalePancreasbusinessFollow-Up Studies

description

BACKGROUND The influence of DNA content on prognosis in stomach cancer has been investigated rarely, and the results are controversial. METHOD The prognostic relevance of the DNA content and histomorphologic parameters was evaluated in 41 patients after resection of pancreatic cancer. RESULTS In the univariate analysis, the DNA content, tumor size, lymph node status, tumor stage, nuclear grade, and type of resection had a statistically significant influence on the prognosis. No association was found between the DNA content and the histomorphologic features. Apart from the operative procedure, the DNA content was the strongest indicator of prognosis in the multivariate analysis. CONCLUSIONS Further investigations are necessary to find out if DNA analysis can be performed preoperatively on material obtained by fine-needle aspiration.

yearjournalcountryeditionlanguage
1994-01-01Cancer
https://doi.org/10.1002/1097-0142(19940101)73:1<63::aid-cncr2820730113>3.0.co;2-p