6533b834fe1ef96bd129cc0b
RESEARCH PRODUCT
Effect of population patchiness and migration rates on the adaptation and divergence of vesicular stomatitis virus quasispecies populations
Andrés MoyaRosario MirallesSantiago F. Elenasubject
PopulationAdaptation BiologicalViral quasispeciesBiologyVesicular stomatitis Indiana virusVirusCell LineDivergenceViral Envelope ProteinsCricetinaeVirologyTumor Cells CulturedAnimalsHumanseducationGeneticseducation.field_of_studyExperimental evolutionMembrane GlycoproteinsModels GeneticGenetic Variationbiology.organism_classificationVirologyHomogeneousVesicular stomatitis virusDirected Molecular EvolutionAdaptationdescription
The effect of migration among different isolated virus quasispecies populations on their adaptation and diversity was analysed through experimental evolution. Anin vitrocell system was employed to simulate migration of vesicular stomatitis virus between isolated homogeneous host cell populations. The results clearly demonstrated a positive correlation between the migration rate and the magnitude of the mean fitness reached by the virus quasispecies populations. The results also showed, although less clearly, that fitness differences among quasispecies decreased with the magnitude of migration. These results are in close agreement with predictions of standard population genetics theory. These results can be explained in terms of the spread of beneficial mutations, originating in a single isolated quasispecies, through the entire system formed by the different quasispecies populations contained in different host cell populations.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1999-08-31 | Journal of General Virology |