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RESEARCH PRODUCT

Gene-diet interaction in plasma lipid response to plant sterols and stanols: A review of clinical trials

Antonio CillaMussa MakranReyes Barberá

subject

Apolipoprotein Emedicine.medical_specialtyLipid-lowering effectMedicine (miscellaneous)Cholesterol 7 alpha-hydroxylaseInterindividual variabilityIntestinal absorptionchemistry.chemical_compoundAPOA4Internal medicinemedicineTX341-641NutrigeneticsGen-dietNutrition and DieteticsbiologyNutrition. Foods and food supplyCholesterolbusiness.industryPlant sterols/stanolsClinical trialEndocrinologychemistryMethylenetetrahydrofolate reductaseABCG5biology.proteinlipids (amino acids peptides and proteins)businessFood Science

description

Abstract Plant sterols and stanols (PS) are well known for their cholesterol-lowering effect by reducing intestinal absorption of cholesterol. However, genetic factors modulate the low-density lipoprotein cholesterol (LDL-C) response to PS therapy. This review examines clinical trials evaluating the impact of the main genes associated with response of plasma lipid concentrations to PS intake: APOE, CYP7A1, ABCG5/G8, NPC1L1, CETP, APOA4/A5, SCARBI, HMGCR, PPARα, LIPC, MTHFR and LPA. Evidence indicates that carriers of mutant allele of the CYP7A1 c. −204 A > C variant experience a greater plasma cholesterol reduction after PS intake, although there is discrepancy for the rest of genetic variants studied. Thus, it is necessary to standardize the design of these studies to validate the use of genetic information as a predictor marker of the response to the intervention with PS, to scientifically validate the use of these data in the personalized dietary advice.

yearjournalcountryeditionlanguage
2021-12-01Journal of Functional Foods
https://doi.org/10.1016/j.jff.2021.104751